Fig. 2
MR associations between genetically determined blood pressure and the risk of AD. Genome-wide significantly associated (P < 5 × 10−8) independent (LD R2 = 0.001, clumping distance = 10,000 kb) SNPs were used as instruments. Abbreviations: MR, Mendelian randomization; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; LD, linkage disequilibrium