Fig. 9
From: CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease
Schematic model of CERTL action in AD. a CERTL concentration is decreased in AD neuronal cells. Consequently, the transport of Cer to the Golgi is impaired and Cer accumulates in the cell. Cer elevation stabilizes and favors the secretases activity. The amyloidogenic APP processing is favored and Aβ is produced. The neighboring microglia changes the resting status to activate. b By overexpressing CERTL, the physiological transfer of Cer from the ER to the Golgi is restored favoring SM synthesis, which is intensified. The reduction of Cer levels in neuronal cells diminished secretases activity, reducing Aβ biogenesis. The interaction between CERTL and APP may be important in stabilizing APP in the membrane and in protecting APP from secretase activity. Furthermore, CERTL affects Aβ fibrilization by organizing Aβ into less neurotoxic aggregates that may be cleared from the brain more easily and reduces the number of activated microglia