TY - JOUR AU - Rogers, J. AU - Morrison, J. H. PY - 1985 DA - 1985// TI - Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer’s disease JO - J Neurosci VL - 5 UR - https://doi.org/10.1523/JNEUROSCI.05-10-02801.1985 DO - 10.1523/JNEUROSCI.05-10-02801.1985 ID - Rogers1985 ER - TY - JOUR AU - Kawasaki, H. AU - Murayama, S. AU - Tomonaga, M. AU - Izumiyama, N. AU - Shimada, H. PY - 1987 DA - 1987// TI - Neurofibrillary tangles in human upper cervical ganglia. Morphological study with immunohistochemistry and electron microscopy JO - Acta Neuropathol VL - 75 UR - https://doi.org/10.1007/BF00687076 DO - 10.1007/BF00687076 ID - Kawasaki1987 ER - TY - JOUR AU - Wisniewski, H. M. AU - Kozlowski, P. B. PY - 1982 DA - 1982// TI - Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT) JO - Ann N Y Acad Sci VL - 396 UR - https://doi.org/10.1111/j.1749-6632.1982.tb26848.x DO - 10.1111/j.1749-6632.1982.tb26848.x ID - Wisniewski1982 ER - TY - JOUR AU - Krabbe, G. AU - Halle, A. AU - Matyash, V. AU - Rinnenthal, J. L. AU - Eom, G. D. AU - Bernhardt, U. PY - 2013 DA - 2013// TI - Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0060921 DO - 10.1371/journal.pone.0060921 ID - Krabbe2013 ER - TY - STD TI - Crivelli SM, Giovagnoni C, Visseren L, Scheithauer AL, de Wit N, den Hoedt S, et al. Sphingolipids in Alzheimer’s disease, how can we target them? Adv Drug Deliv Rev. 2020. ID - ref5 ER - TY - JOUR AU - Hannun, Y. A. AU - Obeid, L. M. PY - 2008 DA - 2008// TI - Principles of bioactive lipid signalling: lessons from sphingolipids JO - Nat Rev Mol Cell Biol VL - 9 UR - https://doi.org/10.1038/nrm2329 DO - 10.1038/nrm2329 ID - Hannun2008 ER - TY - JOUR AU - Zhang, Y. AU - Li, X. AU - Becker, K. A. AU - Gulbins, E. PY - 2009 DA - 2009// TI - Ceramide-enriched membrane domains--structure and function JO - Biochim Biophys Acta VL - 1788 UR - https://doi.org/10.1016/j.bbamem.2008.07.030 DO - 10.1016/j.bbamem.2008.07.030 ID - Zhang2009 ER - TY - JOUR AU - Schwarz, A. AU - Futerman, A. H. PY - 1997 DA - 1997// TI - Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth JO - J Neurosci VL - 17 UR - https://doi.org/10.1523/JNEUROSCI.17-09-02929.1997 DO - 10.1523/JNEUROSCI.17-09-02929.1997 ID - Schwarz1997 ER - TY - JOUR AU - Zhang, H. AU - Desai, N. N. AU - Olivera, A. AU - Seki, T. AU - Brooker, G. AU - Spiegel, S. PY - 1991 DA - 1991// TI - Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation JO - J Cell Biol VL - 114 UR - https://doi.org/10.1083/jcb.114.1.155 DO - 10.1083/jcb.114.1.155 ID - Zhang1991 ER - TY - JOUR AU - Bartke, N. AU - Hannun, Y. A. PY - 2009 DA - 2009// TI - Bioactive sphingolipids: metabolism and function JO - J Lipid Res VL - 50 UR - https://doi.org/10.1194/jlr.R800080-JLR200 DO - 10.1194/jlr.R800080-JLR200 ID - Bartke2009 ER - TY - JOUR AU - Perry, D. K. AU - Hannun, Y. A. PY - 1998 DA - 1998// TI - The role of ceramide in cell signaling JO - Biochim Biophys Acta VL - 1436 UR - https://doi.org/10.1016/S0005-2760(98)00145-3 DO - 10.1016/S0005-2760(98)00145-3 ID - Perry1998 ER - TY - JOUR AU - Meer, G. AU - Holthuis, J. C. PY - 2000 DA - 2000// TI - Sphingolipid transport in eukaryotic cells JO - Biochim Biophys Acta VL - 1486 UR - https://doi.org/10.1016/S1388-1981(00)00054-8 DO - 10.1016/S1388-1981(00)00054-8 ID - Meer2000 ER - TY - JOUR AU - Cutler, R. G. AU - Kelly, J. AU - Storie, K. AU - Pedersen, W. A. AU - Tammara, A. AU - Hatanpaa, K. PY - 2004 DA - 2004// TI - Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease JO - Proc Natl Acad Sci U S A VL - 101 UR - https://doi.org/10.1073/pnas.0305799101 DO - 10.1073/pnas.0305799101 ID - Cutler2004 ER - TY - JOUR AU - Mielke, M. M. AU - Bandaru, V. V. AU - Haughey, N. J. AU - Xia, J. AU - Fried, L. P. AU - Yasar, S. PY - 2012 DA - 2012// TI - Serum ceramides increase the risk of Alzheimer disease: the Women’s Health and Aging Study II JO - Neurology. VL - 79 UR - https://doi.org/10.1212/WNL.0b013e318264e380 DO - 10.1212/WNL.0b013e318264e380 ID - Mielke2012 ER - TY - JOUR AU - He, X. AU - Huang, Y. AU - Li, B. AU - Gong, C. X. AU - Schuchman, E. H. PY - 2010 DA - 2010// TI - Deregulation of sphingolipid metabolism in Alzheimer’s disease JO - Neurobiol Aging VL - 31 UR - https://doi.org/10.1016/j.neurobiolaging.2008.05.010 DO - 10.1016/j.neurobiolaging.2008.05.010 ID - He2010 ER - TY - STD TI - de Wit NM, Snkhchyan H, den Hoedt S, Wattimena D, de Vos R, Mulder MT, et al. Altered sphingolipid balance in capillary cerebral amyloid angiopathy. J Alzheimers Dis. 2016. ID - ref16 ER - TY - JOUR AU - Fabelo, N. AU - Martin, V. AU - Marin, R. AU - Moreno, D. AU - Ferrer, I. AU - Diaz, M. PY - 2014 DA - 2014// TI - Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer’s disease and facilitates APP/BACE1 interactions JO - Neurobiol Aging VL - 35 UR - https://doi.org/10.1016/j.neurobiolaging.2014.02.005 DO - 10.1016/j.neurobiolaging.2014.02.005 ID - Fabelo2014 ER - TY - JOUR AU - Lee, J. T. AU - Xu, J. AU - Lee, J. M. AU - Ku, G. AU - Han, X. AU - Yang, D. I. PY - 2004 DA - 2004// TI - Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway JO - J Cell Biol VL - 164 UR - https://doi.org/10.1083/jcb.200307017 DO - 10.1083/jcb.200307017 ID - Lee2004 ER - TY - JOUR AU - Malaplate-Armand, C. AU - Florent-Bechard, S. AU - Youssef, I. AU - Koziel, V. AU - Sponne, I. AU - Kriem, B. PY - 2006 DA - 2006// TI - Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway JO - Neurobiol Dis VL - 23 UR - https://doi.org/10.1016/j.nbd.2006.02.010 DO - 10.1016/j.nbd.2006.02.010 ID - Malaplate-Armand2006 ER - TY - JOUR AU - Isobe, C. AU - Abe, T. AU - Terayama, Y. PY - 2010 DA - 2010// TI - Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2′-deoxyguanosine in the CSF of patients with Alzheimer’s disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process JO - J Neurol VL - 257 UR - https://doi.org/10.1007/s00415-009-5333-x DO - 10.1007/s00415-009-5333-x ID - Isobe2010 ER - TY - JOUR AU - Puglielli, L. AU - Ellis, B. C. AU - Saunders, A. J. AU - Kovacs, D. M. PY - 2003 DA - 2003// TI - Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M300466200 DO - 10.1074/jbc.M300466200 ID - Puglielli2003 ER - TY - JOUR AU - Takasugi, N. AU - Sasaki, T. AU - Shinohara, M. AU - Iwatsubo, T. AU - Tomita, T. PY - 2015 DA - 2015// TI - Synthetic ceramide analogues increase amyloid-beta 42 production by modulating gamma-secretase activity JO - Biochem Biophys Res Commun VL - 457 UR - https://doi.org/10.1016/j.bbrc.2014.12.087 DO - 10.1016/j.bbrc.2014.12.087 ID - Takasugi2015 ER - TY - JOUR AU - Hanada, K. AU - Kumagai, K. AU - Yasuda, S. AU - Miura, Y. AU - Kawano, M. AU - Fukasawa, M. PY - 2003 DA - 2003// TI - Molecular machinery for non-vesicular trafficking of ceramide JO - Nature. VL - 426 UR - https://doi.org/10.1038/nature02188 DO - 10.1038/nature02188 ID - Hanada2003 ER - TY - JOUR AU - Mencarelli, C. AU - Losen, M. AU - Hammels, C. AU - Vry, J. AU - Hesselink, M. K. AU - Steinbusch, H. W. PY - 2010 DA - 2010// TI - The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function? JO - J Neurochem VL - 113 ID - Mencarelli2010 ER - TY - JOUR AU - Crivelli, S. M. AU - Paulus, A. AU - Markus, J. AU - Bauwens, M. AU - Berkes, D. AU - Vries, H. E. PY - 2017 DA - 2017// TI - Synthesis, radiosynthesis, and preliminary in vitro and in vivo evaluation of the fluorinated ceramide trafficking inhibitor (HPA-12) for brain applications JO - J Alzheimers Dis VL - 60 UR - https://doi.org/10.3233/JAD-161231 DO - 10.3233/JAD-161231 ID - Crivelli2017 ER - TY - JOUR AU - Wang, X. AU - Rao, R. P. AU - Kosakowska-Cholody, T. AU - Masood, M. A. AU - Southon, E. AU - Zhang, H. PY - 2009 DA - 2009// TI - Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice JO - J Cell Biol VL - 184 UR - https://doi.org/10.1083/jcb.200807176 DO - 10.1083/jcb.200807176 ID - Wang2009 ER - TY - JOUR AU - Yasuda, S. AU - Kitagawa, H. AU - Ueno, M. AU - Ishitani, H. AU - Fukasawa, M. AU - Nishijima, M. PY - 2001 DA - 2001// TI - A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M104884200 DO - 10.1074/jbc.M104884200 ID - Yasuda2001 ER - TY - JOUR AU - Yamaji, T. AU - Hanada, K. PY - 2014 DA - 2014// TI - Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0088124 DO - 10.1371/journal.pone.0088124 ID - Yamaji2014 ER - TY - JOUR AU - Mencarelli, C. AU - Bode, G. H. AU - Losen, M. AU - Kulharia, M. AU - Molenaar, P. C. AU - Veerhuis, R. PY - 2012 DA - 2012// TI - Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M111.299545 DO - 10.1074/jbc.M111.299545 ID - Mencarelli2012 ER - TY - JOUR AU - Revert, F. AU - Ventura, I. AU - Martinez-Martinez, P. AU - Granero-Molto, F. AU - Revert-Ros, F. AU - Macias, J. PY - 2008 DA - 2008// TI - Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen. Identification of novel membrane-bound isoforms JO - J Biol Chem VL - 283 UR - https://doi.org/10.1074/jbc.M805026200 DO - 10.1074/jbc.M805026200 ID - Revert2008 ER - TY - JOUR AU - Bode, G. H. AU - Losen, M. AU - Buurman, W. A. AU - Veerhuis, R. AU - Molenaar, P. C. AU - Steinbusch, H. W. PY - 2014 DA - 2014// TI - Complement activation by ceramide transporter proteins JO - J Immunol VL - 192 UR - https://doi.org/10.4049/jimmunol.1301673 DO - 10.4049/jimmunol.1301673 ID - Bode2014 ER - TY - JOUR AU - Oakley, H. AU - Cole, S. L. AU - Logan, S. AU - Maus, E. AU - Shao, P. AU - Craft, J. PY - 2006 DA - 2006// TI - Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer’s disease mutations: potential factors in amyloid plaque formation JO - J Neurosci VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.1202-06.2006 DO - 10.1523/JNEUROSCI.1202-06.2006 ID - Oakley2006 ER - TY - JOUR AU - Fluhrer, R. AU - Multhaup, G. AU - Schlicksupp, A. AU - Okochi, M. AU - Takeda, M. AU - Lammich, S. PY - 2003 DA - 2003// TI - Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M211485200 DO - 10.1074/jbc.M211485200 ID - Fluhrer2003 ER - TY - JOUR AU - Wang, G. AU - Silva, J. AU - Dasgupta, S. AU - Bieberich, E. PY - 2008 DA - 2008// TI - Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes JO - Glia. VL - 56 UR - https://doi.org/10.1002/glia.20626 DO - 10.1002/glia.20626 ID - Wang2008 ER - TY - JOUR AU - Collingwood, J. AU - Khan, A. AU - Korchazkina, O. AU - Berthon, G. AU - Exley, C. PY - 2004 DA - 2004// TI - Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of A beta (42) in a manner which may have consequences for metal chelation therapy in Alzheimer’s disease JO - J Alzheimers Dis VL - 6 UR - https://doi.org/10.3233/JAD-2004-6310 DO - 10.3233/JAD-2004-6310 ID - Collingwood2004 ER - TY - JOUR AU - Mold, M. AU - Ouro-Gnao, L. AU - Wieckowski, B. M. AU - Exley, C. PY - 2013 DA - 2013// TI - Copper prevents amyloid-beta (1-42) from forming amyloid fibrils under near-physiological conditions in vitro JO - Sci Rep VL - 3 UR - https://doi.org/10.1038/srep01256 DO - 10.1038/srep01256 ID - Mold2013 ER - TY - JOUR AU - Kugler, S. AU - Lingor, P. AU - Scholl, U. AU - Zolotukhin, S. AU - Bahr, M. PY - 2003 DA - 2003// TI - Differential transgene expression in brain cells in vivo and in vitro from AAV-2 vectors with small transcriptional control units JO - Virology. VL - 311 UR - https://doi.org/10.1016/S0042-6822(03)00162-4 DO - 10.1016/S0042-6822(03)00162-4 ID - Kugler2003 ER - TY - JOUR AU - Verhaagen, J. AU - Hobo, B. AU - Ehlert, E. M. E. AU - Eggers, R. AU - Korecka, J. A. AU - Hoyng, S. A. PY - 2018 DA - 2018// TI - Small scale production of recombinant adeno-associated viral vectors for gene delivery to the nervous system JO - Methods Mol Biol VL - 1715 UR - https://doi.org/10.1007/978-1-4939-7522-8_1 DO - 10.1007/978-1-4939-7522-8_1 ID - Verhaagen2018 ER - TY - BOOK PY - 1997 DA - 1997// TI - The mouse brain in stereotaxic coordinates PB - Academic Press CY - San Diego ID - ref39 ER - TY - JOUR AU - Prickaerts, J. AU - Moechars, D. AU - Cryns, K. AU - Lenaerts, I. AU - Craenendonck, H. AU - Goris, I. PY - 2006 DA - 2006// TI - Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania JO - J Neurosci VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.5216-05.2006 DO - 10.1523/JNEUROSCI.5216-05.2006 ID - Prickaerts2006 ER - TY - JOUR AU - Sierksma, A. S. AU - Prickaerts, J. AU - Chouliaras, L. AU - Rostamian, S. AU - Delbroek, L. AU - Rutten, B. P. PY - 2013 DA - 2013// TI - Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice JO - Neurobiol Aging VL - 34 UR - https://doi.org/10.1016/j.neurobiolaging.2012.05.012 DO - 10.1016/j.neurobiolaging.2012.05.012 ID - Sierksma2013 ER - TY - STD TI - Young K, Morrison H. Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using ImageJ. J Vis Exp. 2018;136. ID - ref42 ER - TY - JOUR AU - Blachnio-Zabielska, A. U. AU - Persson, X. M. AU - Koutsari, C. AU - Zabielski, P. AU - Jensen, M. D. PY - 2012 DA - 2012// TI - A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans JO - Rapid Commun Mass Spectrom VL - 26 UR - https://doi.org/10.1002/rcm.6216 DO - 10.1002/rcm.6216 ID - Blachnio-Zabielska2012 ER - TY - JOUR AU - Hoogendoorn, A. AU - Hoedt, S. AU - Hartman, E. M. J. AU - Krabbendam-Peters, I. AU - Lintel, H. M. AU - Zee, L. PY - 2019 DA - 2019// TI - Variation in coronary atherosclerosis severity related to a distinct LDL (low-density lipoprotein) profile: findings from a familial hypercholesterolemia pig model JO - Arterioscler Thromb Vasc Biol VL - 39 UR - https://doi.org/10.1161/ATVBAHA.119.313246 DO - 10.1161/ATVBAHA.119.313246 ID - Hoogendoorn2019 ER - TY - JOUR AU - Schmittgen, T. D. AU - Livak, K. J. PY - 2008 DA - 2008// TI - Analyzing real-time PCR data by the comparative C(T) method JO - Nat Protoc VL - 3 UR - https://doi.org/10.1038/nprot.2008.73 DO - 10.1038/nprot.2008.73 ID - Schmittgen2008 ER - TY - JOUR AU - Gras, S. L. AU - Waddington, L. J. AU - Goldie, K. N. PY - 2011 DA - 2011// TI - Transmission electron microscopy of amyloid fibrils JO - Methods Mol Biol VL - 752 UR - https://doi.org/10.1007/978-1-60327-223-0_13 DO - 10.1007/978-1-60327-223-0_13 ID - Gras2011 ER - TY - JOUR AU - Oakley, H. AU - Cole, S. L. AU - Logan, S. AU - Maus, E. AU - Shao, P. AU - Craft, J. PY - 2006 DA - 2006// TI - Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer’s disease mutations: potential factors in amyloid plaque formation JO - J Neurosci VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.1202-06.2006 DO - 10.1523/JNEUROSCI.1202-06.2006 ID - Oakley2006 ER - TY - JOUR AU - Ohno, M. AU - Cole, S. L. AU - Yasvoina, M. AU - Zhao, J. AU - Citron, M. AU - Berry, R. PY - 2007 DA - 2007// TI - BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice JO - Neurobiol Dis VL - 26 UR - https://doi.org/10.1016/j.nbd.2006.12.008 DO - 10.1016/j.nbd.2006.12.008 ID - Ohno2007 ER - TY - JOUR AU - Kimura, R. AU - Devi, L. AU - Ohno, M. PY - 2010 DA - 2010// TI - Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice JO - J Neurochem VL - 113 UR - https://doi.org/10.1111/j.1471-4159.2010.06608.x DO - 10.1111/j.1471-4159.2010.06608.x ID - Kimura2010 ER - TY - JOUR AU - Fukumoto, H. AU - Cheung, B. S. AU - Hyman, B. T. AU - Irizarry, M. C. PY - 2002 DA - 2002// TI - Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease JO - Arch Neurol VL - 59 UR - https://doi.org/10.1001/archneur.59.9.1381 DO - 10.1001/archneur.59.9.1381 ID - Fukumoto2002 ER - TY - JOUR AU - Matarin, M. AU - Salih, D. A. AU - Yasvoina, M. AU - Cummings, D. M. AU - Guelfi, S. AU - Liu, W. PY - 2015 DA - 2015// TI - A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology JO - Cell Rep VL - 10 UR - https://doi.org/10.1016/j.celrep.2014.12.041 DO - 10.1016/j.celrep.2014.12.041 ID - Matarin2015 ER - TY - JOUR AU - Bandet, C. L. AU - Mahfouz, R. AU - Veret, J. AU - Sotiropoulos, A. AU - Poirier, M. AU - Giussani, P. PY - 2018 DA - 2018// TI - Ceramide transporter CERT is involved in muscle insulin signaling defects under lipotoxic conditions JO - Diabetes. VL - 67 UR - https://doi.org/10.2337/db17-0901 DO - 10.2337/db17-0901 ID - Bandet2018 ER - TY - JOUR AU - Kumagai, K. AU - Yasuda, S. AU - Okemoto, K. AU - Nishijima, M. AU - Kobayashi, S. AU - Hanada, K. PY - 2005 DA - 2005// TI - CERT mediates intermembrane transfer of various molecular species of ceramides JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M409290200 DO - 10.1074/jbc.M409290200 ID - Kumagai2005 ER - TY - JOUR AU - Strooper, B. AU - Annaert, W. PY - 2000 DA - 2000// TI - Proteolytic processing and cell biological functions of the amyloid precursor protein JO - J Cell Sci VL - 113 ID - Strooper2000 ER - TY - JOUR AU - Girard, S. D. AU - Jacquet, M. AU - Baranger, K. AU - Migliorati, M. AU - Escoffier, G. AU - Bernard, A. PY - 2014 DA - 2014// TI - Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer’s disease JO - Hippocampus. VL - 24 UR - https://doi.org/10.1002/hipo.22267 DO - 10.1002/hipo.22267 ID - Girard2014 ER - TY - JOUR AU - Savage, J. C. AU - Jay, T. AU - Goduni, E. AU - Quigley, C. AU - Mariani, M. M. AU - Malm, T. PY - 2015 DA - 2015// TI - Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer’s disease JO - J Neurosci VL - 35 UR - https://doi.org/10.1523/JNEUROSCI.4586-14.2015 DO - 10.1523/JNEUROSCI.4586-14.2015 ID - Savage2015 ER - TY - JOUR AU - Kanazawa, H. AU - Ohsawa, K. AU - Sasaki, Y. AU - Kohsaka, S. AU - Imai, Y. PY - 2002 DA - 2002// TI - Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M109218200 DO - 10.1074/jbc.M109218200 ID - Kanazawa2002 ER - TY - JOUR AU - Olabarria, M. AU - Noristani, H. N. AU - Verkhratsky, A. AU - Rodriguez, J. J. PY - 2010 DA - 2010// TI - Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer’s disease JO - Glia. VL - 58 ID - Olabarria2010 ER - TY - JOUR AU - Dinkins, M. B. AU - Enasko, J. AU - Hernandez, C. AU - Wang, G. AU - Kong, J. AU - Helwa, I. PY - 2016 DA - 2016// TI - Neutral sphingomyelinase-2 deficiency ameliorates Alzheimer’s disease pathology and improves cognition in the 5XFAD mouse JO - J Neurosci VL - 36 UR - https://doi.org/10.1523/JNEUROSCI.1429-16.2016 DO - 10.1523/JNEUROSCI.1429-16.2016 ID - Dinkins2016 ER - TY - JOUR AU - Beher, D. AU - Hesse, L. AU - Masters, C. L. AU - Multhaup, G. PY - 1996 DA - 1996// TI - Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I JO - J Biol Chem VL - 271 UR - https://doi.org/10.1074/jbc.271.3.1613 DO - 10.1074/jbc.271.3.1613 ID - Beher1996 ER - TY - JOUR AU - Multhaup, G. PY - 1994 DA - 1994// TI - Identification and regulation of the high affinity binding site of the Alzheimer’s disease amyloid protein precursor (APP) to glycosaminoglycans JO - Biochimie. VL - 76 UR - https://doi.org/10.1016/0300-9084(94)90163-5 DO - 10.1016/0300-9084(94)90163-5 ID - Multhaup1994 ER - TY - JOUR AU - Breen, K. C. AU - Bruce, M. AU - Anderton, B. H. PY - 1991 DA - 1991// TI - Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion JO - J Neurosci Res VL - 28 UR - https://doi.org/10.1002/jnr.490280109 DO - 10.1002/jnr.490280109 ID - Breen1991 ER - TY - JOUR AU - Turner, N. AU - Mason, P. J. AU - Brown, R. AU - Fox, M. AU - Povey, S. AU - Rees, A. PY - 1992 DA - 1992// TI - Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen JO - J Clin Invest VL - 89 UR - https://doi.org/10.1172/JCI115625 DO - 10.1172/JCI115625 ID - Turner1992 ER - TY - JOUR AU - Verdier, Y. AU - Zarandi, M. AU - Penke, B. PY - 2004 DA - 2004// TI - Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer’s disease JO - J Pept Sci VL - 10 UR - https://doi.org/10.1002/psc.573 DO - 10.1002/psc.573 ID - Verdier2004 ER - TY - JOUR AU - Ebel, P. AU - Vom Dorp, K. AU - Petrasch-Parwez, E. AU - Zlomuzica, A. AU - Kinugawa, K. AU - Mariani, J. PY - 2013 DA - 2013// TI - Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.479907 DO - 10.1074/jbc.M113.479907 ID - Ebel2013 ER - TY - JOUR AU - Imgrund, S. AU - Hartmann, D. AU - Farwanah, H. AU - Eckhardt, M. AU - Sandhoff, R. AU - Degen, J. PY - 2009 DA - 2009// TI - Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M109.031971 DO - 10.1074/jbc.M109.031971 ID - Imgrund2009 ER - TY - JOUR AU - Salegio, E. A. AU - Samaranch, L. AU - Jenkins, R. W. AU - Clarke, C. J. AU - Lamarre, C. AU - Beyer, J. PY - 2012 DA - 2012// TI - Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain JO - Hum Gene Ther VL - 23 UR - https://doi.org/10.1089/hum.2012.052 DO - 10.1089/hum.2012.052 ID - Salegio2012 ER - TY - JOUR AU - Flanigan, T. J. AU - Xue, Y. AU - Kishan Rao, S. AU - Dhanushkodi, A. AU - McDonald, M. P. PY - 2014 DA - 2014// TI - Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics JO - Genes Brain Behav VL - 13 UR - https://doi.org/10.1111/gbb.12133 DO - 10.1111/gbb.12133 ID - Flanigan2014 ER - TY - JOUR AU - Jawhar, S. AU - Trawicka, A. AU - Jenneckens, C. AU - Bayer, T. A. AU - Wirths, O. PY - 2012 DA - 2012// TI - Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer’s disease JO - Neurobiol Aging VL - 33 UR - https://doi.org/10.1016/j.neurobiolaging.2010.05.027 DO - 10.1016/j.neurobiolaging.2010.05.027 ID - Jawhar2012 ER - TY - JOUR AU - Richard, B. C. AU - Kurdakova, A. AU - Baches, S. AU - Bayer, T. A. AU - Weggen, S. AU - Wirths, O. PY - 2015 DA - 2015// TI - Gene dosage dependent aggravation of the neurological phenotype in the 5XFAD mouse model of Alzheimer’s disease JO - J Alzheimers Dis VL - 45 UR - https://doi.org/10.3233/JAD-143120 DO - 10.3233/JAD-143120 ID - Richard2015 ER - TY - JOUR AU - Wu, D. AU - Tang, X. AU - Gu, L. H. AU - Li, X. L. AU - Qi, X. Y. AU - Bai, F. PY - 2018 DA - 2018// TI - LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5XFAD mice JO - CNS Neurosci Ther VL - 24 UR - https://doi.org/10.1111/cns.12809 DO - 10.1111/cns.12809 ID - Wu2018 ER - TY - JOUR AU - Gu, L. AU - Wu, D. AU - Tang, X. AU - Qi, X. AU - Li, X. AU - Bai, F. PY - 2018 DA - 2018// TI - Myelin changes at the early stage of 5XFAD mice JO - Brain Res Bull VL - 137 UR - https://doi.org/10.1016/j.brainresbull.2017.12.013 DO - 10.1016/j.brainresbull.2017.12.013 ID - Gu2018 ER - TY - JOUR AU - Katsel, P. AU - Li, C. AU - Haroutunian, V. PY - 2007 DA - 2007// TI - Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer’s disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease? JO - Neurochem Res VL - 32 UR - https://doi.org/10.1007/s11064-007-9297-x DO - 10.1007/s11064-007-9297-x ID - Katsel2007 ER - TY - JOUR AU - Couttas, T. A. AU - Kain, N. AU - Tran, C. AU - Chatterton, Z. AU - Kwok, J. B. AU - Don, A. S. PY - 2018 DA - 2018// TI - Age-dependent changes to sphingolipid balance in the human hippocampus are gender-specific and may sensitize to neurodegeneration JO - J Alzheimers Dis VL - 63 UR - https://doi.org/10.3233/JAD-171054 DO - 10.3233/JAD-171054 ID - Couttas2018 ER - TY - STD TI - Han X, D MH, McKeel DW, Jr., Kelley J, Morris JC. Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer’s disease: potential role in disease pathogenesis. J Neurochem 2002;82(4):809–818. ID - ref75 ER - TY - STD TI - Barrier L, Fauconneau B, Noel A, Ingrand S. Ceramide and related-sphingolipid levels are not altered in disease-associated brain regions of APP and APP/PS1 mouse models of Alzheimer’s disease: relationship with the lack of neurodegeneration? Int J Alzheimers Dis. 2011;2011:920958. ID - ref76 ER - TY - JOUR AU - Thinakaran, G. AU - Koo, E. H. PY - 2008 DA - 2008// TI - Amyloid precursor protein trafficking, processing, and function JO - J Biol Chem VL - 283 UR - https://doi.org/10.1074/jbc.R800019200 DO - 10.1074/jbc.R800019200 ID - Thinakaran2008 ER - TY - JOUR AU - Lopez-Montero, I. AU - Rodriguez, N. AU - Cribier, S. AU - Pohl, A. AU - Velez, M. AU - Devaux, P. F. PY - 2005 DA - 2005// TI - Rapid transbilayer movement of ceramides in phospholipid vesicles and in human erythrocytes JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M412052200 DO - 10.1074/jbc.M412052200 ID - Lopez-Montero2005 ER - TY - JOUR AU - Silva, L. AU - Almeida, R. F. AU - Fedorov, A. AU - Matos, A. P. AU - Prieto, M. PY - 2006 DA - 2006// TI - Ceramide-platform formation and -induced biophysical changes in a fluid phospholipid membrane JO - Mol Membr Biol VL - 23 UR - https://doi.org/10.1080/09687860500439474 DO - 10.1080/09687860500439474 ID - Silva2006 ER - TY - JOUR AU - Heppner, F. L. AU - Ransohoff, R. M. AU - Becher, B. PY - 2015 DA - 2015// TI - Immune attack: the role of inflammation in Alzheimer disease JO - Nat Rev Neurosci VL - 16 UR - https://doi.org/10.1038/nrn3880 DO - 10.1038/nrn3880 ID - Heppner2015 ER - TY - JOUR AU - Wang, G. AU - Dinkins, M. AU - He, Q. AU - Zhu, G. AU - Poirier, C. AU - Campbell, A. PY - 2012 DA - 2012// TI - Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD) JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M112.340513 DO - 10.1074/jbc.M112.340513 ID - Wang2012 ER - TY - JOUR AU - Dinkins, M. B. AU - Dasgupta, S. AU - Wang, G. AU - Zhu, G. AU - Bieberich, E. PY - 2014 DA - 2014// TI - Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer’s disease JO - Neurobiol Aging VL - 35 UR - https://doi.org/10.1016/j.neurobiolaging.2014.02.012 DO - 10.1016/j.neurobiolaging.2014.02.012 ID - Dinkins2014 ER - TY - JOUR AU - Wit, N. M. AU - Hoedt, S. AU - Martinez-Martinez, P. AU - Rozemuller, A. J. AU - Mulder, M. T. AU - Vries, H. E. PY - 2019 DA - 2019// TI - Astrocytic ceramide as possible indicator of neuroinflammation JO - J Neuroinflammation VL - 16 UR - https://doi.org/10.1186/s12974-019-1436-1 DO - 10.1186/s12974-019-1436-1 ID - Wit2019 ER - TY - JOUR AU - Elsherbini, A. AU - Kirov, A. S. AU - Dinkins, M. B. AU - Wang, G. AU - Qin, H. AU - Zhu, Z. PY - 2020 DA - 2020// TI - Association of Abeta with ceramide-enriched astrosomes mediates Abeta neurotoxicity JO - Acta Neuropathol Commun VL - 8 UR - https://doi.org/10.1186/s40478-020-00931-8 DO - 10.1186/s40478-020-00931-8 ID - Elsherbini2020 ER -