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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer’s disease progression based on the “brain-gut” axis through multiple integrated omics

Fig. 2

HLJDD reduced Aβ plaque pathology in Tg-APP/PS1 mice. a Congo red staining reveals that Tg-APP/PS1 mice harbour more Aβ plaque with higher density and larger area in the hippocampus (left) and cortex (right) than WT mice, × 20 magnification, (n = 3). b Meanwhile, the results of immunohistochemistry in the hippocampus (left, × 8 magnification) and cortex (right, × 10 magnification) of Tg-APP/PS1 mice were also positive, (n = 3). c The level of Aβ in the CNS of mice was quantified by detecting the value of Integrated option density (IOD). HLJDD significantly suppressed the accumulation of A plaques in the cortex and hippocampus. d The levels of brain SOD (n = 5), MDA (n = 6), and GPX1 (n = 6) were detected by ELISA. All data were analysed by one-way ANOVA with Dunnett-test. All the results are expressed as the mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Alzheimer's Research & Therapy

ISSN: 1758-9193