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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer’s disease progression based on the “brain-gut” axis through multiple integrated omics

Fig. 1

HLJDD ameliorates cognitive deficiency in APP/PS1 mice. a Acquisition of spatial memory was evaluated by the MWM test (n = 11). In the navigation test, mice were evaluated for the total time of four trainings spent searching for the platform location during the day. The Tg-APP/PS1 mice required a longer time than the control group to locate the platform on the training days (P < 0.0001). This significant difference constantly appeared from the first day. b In the space probe trial, the distance percentage, time percentage, and times across platform in the target quadrant were used for evaluation. All of them were reduced in Tg-APP/PS1 mice. In contrast, the chronic administration of HLJDD for 4 months, including H-L and H-H, significantly ameliorated memory and spatial learning deficits of Tg-APP/PS1 mice. c Real-time monitoring of the mouse motion track MWM test experiment. WT, wide mice; Tg, Tg-APP/PS1 mice; H-L, HLJDD with low dosage; H-H, HLJDD with high dosage; Ber, berberine; Don, donepezil. All data were analysed by one-way ANOVA with Dunnett-test. All the results are expressed as the mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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