| |
Overall
|
APOE ε4 non-carriers
|
APOE ε4 carriers
|
|---|
|
β [95% CI]
|
t
|
df
|
p value
|
β [95% CI]
|
t
|
df
|
p value
|
β [95% CI]
|
t
|
df
|
p value
|
|---|
|
ARBs vs. ACE-Is
|
0.050[0.001, 0.099]
|
1.98
|
533.5
|
0.0483
|
0.085[0.012, 0.158]
|
2.28
|
533.9
|
0.0230
|
0.0471[− 0.012, 0.106]
|
1.56
|
558.9
|
0.1186
|
|
C-ARBs vs. NC-ACE-Is
|
0.044[− 0.012, 0.101]
|
1.54
|
586.1
|
0.1252
|
0.106[0.026, 0.185]
|
2.60
|
647.9
|
0.0095
|
0.020 [− 0.051, 0.091]
|
0.55
|
574.0
|
0.5852
|
|
C-ACE-Is vs. NC-ACE-Is
|
0.012[− 0.061, 0.086]
|
0.33
|
562.0
|
0.7388
|
0.055[− 0.050, 0.161]
|
1.03
|
708.9
|
0.3035
|
− 0.023[− 0.115, 0.069]
|
− 0.49
|
487.1
|
0.6224
|
|
NC-ARBs vs. NC-ACE-Is
|
0.043[− 0.016, 0.102]
|
1.42
|
600.3
|
0.1560
|
0.074[− 0.009, 0.158]
|
1.74
|
694.8
|
0.0816
|
0.024[− 0.049, 0.098]
|
0.65
|
523.3
|
0.5177
|
|
C-ARBs vs. NC-ARBs
|
0.005[− 0.046, 0.055]
|
0.18
|
609.9
|
0.8567
|
0.037[− 0.030, 0.104]
|
1.08
|
994.6
|
0.2822
|
− 0.003[− 0.062, 0.056]
|
− 0.09
|
851.0
|
0.9292
|
|
C-ARBs vs. C-ACE-Is
|
0.036[− 0.010, 0.082]
|
1.53
|
853.1
|
0.1250
|
0.070[0.003, 0.136]
|
2.06
|
606.4
|
0.0400
|
0.035[− 0.020, 0.090]
|
1.24
|
678.5
|
0.2147
|
- Three-way APOE × ARB vs. ACE-I × Time interaction: β = 0.025 [− 0.037, 0.088], t = 0.79, p = 0.4309
- C-ARB: BBB-crossing ARB; C-ACE-I: BBB-crossing ACE-I; NC-ARB: Non-BBB-crossing ARB; NC-ACE-I: Non-BBB-crossing ACE-I
