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Table 2 Rate ratios for relationships between WMS-R LM IIA—Delayed Recall score and ACE-I vs. ARB use over time (n = 1689)

From: The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer’s disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status

 

Overall

APOE ε4 non-carriers

APOE ε4 carriers

RR [95% CI]

z

p value

RR [95% CI]

z

p value

RR [95% CI]

z

p value

ARBs vs. ACE-Is

1.094 [1.007, 1.188]

2.14

0.0327

1.200 [1.064, 1.354]

2.97

0.0030

1.003 [0.897, 1.122]

0.06

0.9568

C-ARBs vs. NC-ACE-Is

1.250 [1.089, 1.434]

3.16

0.0015

1.354 [1.116, 1.642]

3.08

0.0020

1.130 [0.932, 1.371]

1.25

0.2124

C-ACE-Is vs. NC-ACE-Is

1.158 [1.036, 1.293]

2.57

0.0098

1.168 [0.995, 1.385]

1.90

0.0571

1.140 [0.976, 1.331]

1.65

0.0993

NC-ARBs vs. NC-ACE-Is

1.199 [1.055, 1.365]

2.79

0.0054

1.324 [1.108, 1.583]

3.07

0.0021

1.104 [0.923, 1.321]

1.08

0.2785

C-ARBs vs. NC-ARBs

1.042 [0.921, 1.179]

0.65

0.5175

1.022 [0.865, 1.208]

0.26

0.7947

1.024 [0.869, 1.205]

0.28

0.7802

C-ARBs vs. C-ACE-Is

1.080 [0.965, 1.209]

1.34

0.1798

1.159 [0.985, 1.364]

1.78

0.0746

0.992 [0.854, 1.152]

− 0.11

0.9161

  1. Three-way APOE × ARB vs. ACE-I × Time interaction: RR = 1.196 [1.015, 1.410], z = 2.135, p = 0.0328
  2. C-ARB: BBB-crossing ARB; C-ACE-I: BBB-crossing ACE-I; NC-ARB: Non-BBB-crossing ARB; NC-ACE-I: Non-BBB-crossing ACE-I