Detecting Alzheimer’s disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET

Table 1 Demographic characteristics of the Aβ PET sample (N = 140)

	Aβ− (n = 43)	Aβ+ (n = 97)	*t / odds ratio* *[95% CI]*	P
Age	66.6 (11.6)	68.6 (8.7)	0.98 [− 2.01; 5.91]	.33
Education	16.4 (2.9)	16.9 (2.6)	0.97 [− 0.52; 1.53]	.33
Female	17 (40%)	43 (44%)	1.22 [0.55; 2.72]	.71
Non-Hispanic White	38 (88%)	85 (88%)	0.93 [0.24; 3.10]	.99
MCI	29 (67%)	64 (66%)	1.07 [0.47; 2.50]	.99
Amnestic phenotype	14 (33%)	57 (59%)	2.93 [1.31; 6.81]	.006
CDR-SB	2.3 (2.1)	3.1 (2.2)	1.98 [− 0.01; 1.52]	.05
Time difference (yrs)	0.3 (0.3)	0.4 (0.6)	1.74 [− 0.02; 0.30]	.08
Favorites z-score	− 1.3 (1.3) n = 38	− 2.4 (1.1) n = 88	− 4.42 [− 1.54; − 0.58]	< .001
Match z-score	− 2.0 (1.4) n = 42	− 3.6 (2.7) n = 93	− 4.81 [− 2.38; − 0.99]	< .001
Line Orientation z-score	− 0.6 (1.2) n = 41	− 1.2 (2.6) n = 94	− 1.79 [− 1.20; 0.06]	.08
BHS-ECog score	2.0 (0.7) n = 38	2.5 (0.7) n = 85	2.94 [0.14; 0.71]	.005

Data are presented as mean (standard deviation) for continuous variables and n (% of the total sample) for categorical variables. Time difference represents the years between the BHA completion and PET acquisition presented in absolute values. For Brain Health Assessment measures, the number of participants with complete data are included. P values are based on independent sample t-tests for continuous variables and Fisher’s exact tests for categorical variables between Aβ− and Aβ+ groups. The 95% confidence intervals (CI) are reported for mean differences for t-tests and odd ratios for Fisher’s exact tests. BHS-ECog Brain Health Survey Everyday Cognition Scales, CDR-SB Clinical Dementia Rating Scale Sum of Boxes, MCI mild cognitive impairment, PET positron emission tomography, yrs. years

ISSN: 1758-9193