Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

Table 5 Locus discovery analysis pleiotropic loci

Cardiometabolic trait	Locus name	Lead SNP	Chr	Position GRCh37	Effect allele/ other allele	Direction of effect AD/CM	Effect allele frequency	Bivariate P value	AD P value	Cardiometabolic trait P value	Conditional posterior probability of colocalization	Cardiometabolic GWAS
LDL	DOC2A	rs11642612	16	30030195	A/C	+/+	0.62	2.19e−08	5.32e−06	2.68e−06	0.98	Klarin et al. [24]
HDL	SPPL2A	rs12595082	15	51007729	C/T	+/+	0.81	3.27e−08	1.66e−06	1.09e−05	0.95	Klarin et al. [24]
BFP	CCNT2	rs10496731	2	135597628	G/T	+/−	0.48	1.74e−08	1.72e−05	2.67e−05	0.94	Lu et al. [23]
DBP	DOCK4	rs144867634	7	111580166	T/C	+/+	0.98	8.33e−08	5.36e−05	1.089e−07	NA	Evangelou et al. [20]

Chr chromosome of the SNP. Direction of effect first position is the direction of effect of the effect allele on AD and the cardiometabolic trait. Effect allele frequency from the Jansen et al. [17] allele frequency. Conditional posterior probability of colocalization, PP4/ (PP3 + PP4) the results of the trait-trait colocalization analysis

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