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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

Fig. 2

ACE locus. a Pleiotropic signal between DBP, SBP, and AD at the ACE locus, and the eQTL signal for ACE in kidney cortex and cerebellum. b Flowchart of our hypothesized mechanism as to how tissue-specific expression of ACE could mediate the blood pressure (BP) and AD pleiotropic signal at this locus. c Diagram of a hypothesized mechanism by which increased kidney expression of ACE could alter renin expression and thus lead to reduce BP through the feedback loops of the renin-angiotensin system

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Alzheimer's Research & Therapy

ISSN: 1758-9193