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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

Fig. 1

Bivariate GWAS analysis workflow. Starting with all the SNPs that were in both GWAS summary statistics files, we performed a bivariate GWAS and filtered the bivariate significant loci based on their single-trait P values. For the locus discovery experiment, we removed loci that were in LD (1 kG EUR r2 > 0.2) or within 500 kb of a known AD or the cardiometabolic trait being tested according to the GWAS Catalog (dotted line arrows). The filtration steps were followed by trait-trait colocalization to confirm there was evidence of a shared causal SNP between the signals at each locus. Finally, we performed single-tissue-eQTL analysis to identify candidate causal genes for each locus

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