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Table 2 Unadjusted odds ratio and 95% confidence intervals from chi-squared or Fisher’s exact tests across ADP, ADP-LRP, and LRP groups for specific initial cognitive symptoms and APOE ε4 genotype. Logistic regression model with APOE e4 is the exposure, initial cognitive as outcomes, and pathology as subgroups

From: Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer’s and Lewy body neuropathology

ADP

Total

APOE ε4

-ve

APOE ε4

+ve

Chi square

p value

 

Amnestic

1043

480

563

p = 0.054

 

80.40%

78.20%

82.40%

  

Executive/Attention

76

36

40

p = .996

 

5.90%

5.90%

5.90%

  

Language

149

79

70

p = 0.14

 

11.50%

12.90%

10.20%

  

Visualspatial

29

19

10

p = 0.059*

 

2.20%

3.10%

1.50%

  

*Fischer’s exact p value presented as small cell count

LRP-ADP

Total

APOEε4

-ve

APOEε4

+ve

Chi square

p value

Odds ratio

Amnestic

722

262

460

p = 0.01

1.56(1.11-2.19)

81.10%

77%

84%

  

Executive/Attention

58

23

35

p = 0.83

 

6.50%

6.70%

6.40%

  

Language

82

44

38

p = 0.003

0.5 (0.32-0.79)

9.20%

12.90%

6.90%

  

Visualspatial

28

12

16

p = 0.62

 

3.10%

3.50%

2.90%

  

LRP

Total

APOEε4

-ve

APOEε4

+ve

Fishers exact

p value

Odds ratio

Amnestic

52

43

9

p = 0.29

 

58.40%

60.60%

50%

  

Executive/Attention

10

9

1

p = 0.68

 

11.20%

12.70%

5.60%

  

Language

18

17

1

p = 0.1

 

20.20%

23.90%

5.60%

  

Visualspatial

9

2

7

p < 0.0001

21.96(4.02-110.62)

10.10%

2.80%

38.90%