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Table 2 Unadjusted odds ratio and 95% confidence intervals from chi-squared or Fisher’s exact tests across ADP, ADP-LRP, and LRP groups for specific initial cognitive symptoms and APOE ε4 genotype. Logistic regression model with APOE e4 is the exposure, initial cognitive as outcomes, and pathology as subgroups

From: Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer’s and Lewy body neuropathology

ADP Total APOE ε4
-ve
APOE ε4
+ve
Chi square
p value
 
Amnestic 1043 480 563 p = 0.054  
80.40% 78.20% 82.40%   
Executive/Attention 76 36 40 p = .996  
5.90% 5.90% 5.90%   
Language 149 79 70 p = 0.14  
11.50% 12.90% 10.20%   
Visualspatial 29 19 10 p = 0.059*  
2.20% 3.10% 1.50%   
*Fischer’s exact p value presented as small cell count
LRP-ADP Total APOEε4
-ve
APOEε4
+ve
Chi square
p value
Odds ratio
Amnestic 722 262 460 p = 0.01 1.56(1.11-2.19)
81.10% 77% 84%   
Executive/Attention 58 23 35 p = 0.83  
6.50% 6.70% 6.40%   
Language 82 44 38 p = 0.003 0.5 (0.32-0.79)
9.20% 12.90% 6.90%   
Visualspatial 28 12 16 p = 0.62  
3.10% 3.50% 2.90%   
LRP Total APOEε4
-ve
APOEε4
+ve
Fishers exact
p value
Odds ratio
Amnestic 52 43 9 p = 0.29  
58.40% 60.60% 50%   
Executive/Attention 10 9 1 p = 0.68  
11.20% 12.70% 5.60%   
Language 18 17 1 p = 0.1  
20.20% 23.90% 5.60%   
Visualspatial 9 2 7 p < 0.0001 21.96(4.02-110.62)
10.10% 2.80% 38.90%   
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