Skip to main content

Table 5 Percentage reduction of dendritic spine density in PFC, CA1, CA3, and EC areas in vehicle-treated 5xFAD and 5xFAD treated with SLCP in comparison to age-matched WT mice. 6-m 6-month-old, 12-m 12-month-old. *p < 0.05 and **p < 0.01 when compared with vehicle-treated 5xFAD mice

From: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis

Areas Groups Apical branch Basal branch
Primary branch Secondary branch Primary branch Secondary branch
6-m 12-m 6-m 12-m 6-m 12-m 6-m 12-m
PFC 5xFAD + vehicle 47.70 66.45 50.83 61.93 42.34 61.48 62.13 56.87
5xFAD + SLCP 21.66** 30.32** 16.71** 31.55** 27.35** 27.48** 30.06 17.09**
CA1 5xFAD + vehicle 41.88 48.71 45.13 58.58 24.64 47.00 30.86 61.96
5xFAD + SLCP 29.22 20.62** 8.91** 33.18** 8.09** 31.50* 12.67* 29.67**
CA3 5xFAD + vehicle 57.03 67.52 53.49 71.12 30.86 72.84 31.32 60.60
5xFAD + SLCP 33.76** 43.92** 38.10* 39.42** 9.25 24.85** 14.37 20.12**
EC 5xFAD + vehicle 45.67 48.50 43.72 49.18 37.87 45.12 35.99 62.46
5xFAD + SLCP 28.86** 37.78 21.24* 35.20* 20.49* 1.65** 16.21* 31.80**