Skip to main content

Table 4 Percentage pyknotic cells in treated and untreated 5xFAD and age-matched WT mice. *p < 0.05; **p < 0.01 compared to WT + vehicle and WT + SLCP. ↓ decrease, m month

From: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis

Groups Pyknotic cells
PFC CA1 CA3 EC
6 m 12 m 6 m 12 m 6 m 12 m 6 m 12 m
5xFAD + vehicle 22.98** 31.91** 22.14** 36.12** 29.16** 44.89** 20.73 29.79
5xFAD + SLCP 14.15* 18.41* 9.86** 18.27** 22.38** 24.34** 13.17* 15.13*
% ↓ pyknotic cells by SLCP treatment 38.45 42.29 55.45 49.40 23.25 45.76 36.48 49.19
5xFAD + vehicle 36.27 45.89 19.09 20.14 20.88 54.37 Degenerated neurons (fluoro-jade C staining)
5xFAD + SLCP 24.03* 24.00** 7.00* 7.22* 16.50 39.37**
% ↓ FJC + neurons by SLCP treatment 33.73 47.70 63.33 64.11 21.01 26.55