Fig. 1

SLCP treatment improved learning and memory in 5xFAD mice. Six- and twelve-month-old 5xFAD and age-matched control animals were tested on the Morris water maze (MWM) task for 5 days, following 2 months of treatment with SLCP (100 mg/kg) or vehicle. The escape latency (a, b) and path length (c, d) were significantly longer in the case of 12-month-old group of 5xFAD mice in comparison to 5xFAD mice treated with SLCP and WT mice treated with vehicle. e–h After 5 days of training in MWM, all mice were given a 60-s probe trial and the latency to first enter to the target quadrant (e), mean distance from the target (previous location of platform) (F), mean number of entries in target quadrant (G) and the time spent in target quadrant (h) were measured. There was an increase in latency of first entry to the target quadrant (e) for vehicle-treated 5xFAD mice, whereas SLCP treatment prevented this increase. Mean distance from the platform was significantly increased in both 6- and 12-month-old 5xFAD mice (f), but this was prevented by treatment with SLCP. Mean number of entries (g) was not significantly different among all the animal groups. Time spent in the target quadrant was decreased for the 6-, but not the 12-month-old 5xFAD mice (h), and this deficit was mitigated by the SLCP treatment. *p < 0.05, **p < 0.01, and ***p < 0.001 in comparison to WT + Vehicle, 5xFAD + SLCP, and WT + SLCP