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Table 3 mGluR5 binding ([18F]FPEB BPND) in brain regions of interest

From: PET imaging of mGluR5 in Alzheimer’s disease

 BPND—gray matter maskedBPND—partial volume corrected
CN, mean (SD)AD, mean (SD)pCN, mean (SD)AD, mean (SD)p
Primary region
 Hippocampus1.78 (0.61)1.30 (0.33)0.011*2.69 (0.88)2.19 (0.45)0.0499*
 Composite association cortex2.38 (0.76)2.04 (0.29)0.1114.39 (1.30)3.99 (0.47)0.258
Exploratory regions
 Prefrontal cortex2.43 (0.78)2.15 (0.29)0.1974.48 (1.34)4.10 (0.49)0.310
 Entorhinal cortex1.99 (0.72)1.52 (0.43)0.034*3.18 (1.18)2.69 (0.54)0.144
 Parahippocampal gyrus1.96 (0.69)1.58 (0.33)0.0523.26 (1.13)2.86 (0.44)0.199
 Lateral temporal cortex2.43 (0.81)2.03 (0.31)0.0754.24 (1.34)3.78 (0.45)0.204
 Lateral parietal cortex2.32 (0.72)1.97 (0.31)0.0914.44 (1.26)4.01 (0.52)0.211
 Posterior cingulum1.65 (0.64)1.42 (0.30)0.2193.23 (1.05)3.01 (0.45)0.448
 Precuneus2.15 (0.66)1.82 (0.27)0.0794.08 (1.16)3.71 (0.47)0.249
 Occipital cortex2.02 (0.59)1.77 (0.25)0.1203.82 (1.03)3.57 (0.41)0.388
 Caudate2.17 (0.86)1.98 (0.42)0.4393.41 (1.26)3.14 (0.46)0.427
 Putamen2.79 (0.91)2.57 (0.35)0.3814.44 (1.37)4.19 (0.64)0.514
 Pallidum0.96 (0.41)0.81 (0.42)0.3122.50 (1.18)2.30 (0.83)0.599
 Thalamus1.38 (0.61)1.12 (0.27)0.1182.40 (0.91)2.04 (0.41)0.162
  1. Data are mean (SD). BPND binding potential of [18F]FPEB in regions of interest, CN cognitively normal (n = 15), AD Alzheimer’s disease (n = 16). p values are for post hoc two-tailed, unpaired t tests (uncorrected for multiplicity) performed after a linear mixed model analysis of BPND in multiple regions (within-subject factor) between CN and AD diagnostic groups