| |
BPND—gray matter masked
|
BPND—partial volume corrected
|
|---|
|
CN, mean (SD)
|
AD, mean (SD)
|
p
|
CN, mean (SD)
|
AD, mean (SD)
|
p
|
|---|
|
Primary region
|
|
Hippocampus
|
1.78 (0.61)
|
1.30 (0.33)
|
0.011*
|
2.69 (0.88)
|
2.19 (0.45)
|
0.0499*
|
|
Composite association cortex
|
2.38 (0.76)
|
2.04 (0.29)
|
0.111
|
4.39 (1.30)
|
3.99 (0.47)
|
0.258
|
|
Exploratory regions
|
|
Prefrontal cortex
|
2.43 (0.78)
|
2.15 (0.29)
|
0.197
|
4.48 (1.34)
|
4.10 (0.49)
|
0.310
|
|
Entorhinal cortex
|
1.99 (0.72)
|
1.52 (0.43)
|
0.034*
|
3.18 (1.18)
|
2.69 (0.54)
|
0.144
|
|
Parahippocampal gyrus
|
1.96 (0.69)
|
1.58 (0.33)
|
0.052
|
3.26 (1.13)
|
2.86 (0.44)
|
0.199
|
|
Lateral temporal cortex
|
2.43 (0.81)
|
2.03 (0.31)
|
0.075
|
4.24 (1.34)
|
3.78 (0.45)
|
0.204
|
|
Lateral parietal cortex
|
2.32 (0.72)
|
1.97 (0.31)
|
0.091
|
4.44 (1.26)
|
4.01 (0.52)
|
0.211
|
|
Posterior cingulum
|
1.65 (0.64)
|
1.42 (0.30)
|
0.219
|
3.23 (1.05)
|
3.01 (0.45)
|
0.448
|
|
Precuneus
|
2.15 (0.66)
|
1.82 (0.27)
|
0.079
|
4.08 (1.16)
|
3.71 (0.47)
|
0.249
|
|
Occipital cortex
|
2.02 (0.59)
|
1.77 (0.25)
|
0.120
|
3.82 (1.03)
|
3.57 (0.41)
|
0.388
|
|
Caudate
|
2.17 (0.86)
|
1.98 (0.42)
|
0.439
|
3.41 (1.26)
|
3.14 (0.46)
|
0.427
|
|
Putamen
|
2.79 (0.91)
|
2.57 (0.35)
|
0.381
|
4.44 (1.37)
|
4.19 (0.64)
|
0.514
|
|
Pallidum
|
0.96 (0.41)
|
0.81 (0.42)
|
0.312
|
2.50 (1.18)
|
2.30 (0.83)
|
0.599
|
|
Thalamus
|
1.38 (0.61)
|
1.12 (0.27)
|
0.118
|
2.40 (0.91)
|
2.04 (0.41)
|
0.162
|
- Data are mean (SD). BPND binding potential of [18F]FPEB in regions of interest, CN cognitively normal (n = 15), AD Alzheimer’s disease (n = 16). p values are for post hoc two-tailed, unpaired t tests (uncorrected for multiplicity) performed after a linear mixed model analysis of BPND in multiple regions (within-subject factor) between CN and AD diagnostic groups
