| | BPND—gray matter masked | BPND—partial volume corrected |
|---|
| CN, mean (SD) | AD, mean (SD) | p | CN, mean (SD) | AD, mean (SD) | p |
|---|
| Primary region |
| Hippocampus | 1.78 (0.61) | 1.30 (0.33) | 0.011* | 2.69 (0.88) | 2.19 (0.45) | 0.0499* |
| Composite association cortex | 2.38 (0.76) | 2.04 (0.29) | 0.111 | 4.39 (1.30) | 3.99 (0.47) | 0.258 |
| Exploratory regions |
| Prefrontal cortex | 2.43 (0.78) | 2.15 (0.29) | 0.197 | 4.48 (1.34) | 4.10 (0.49) | 0.310 |
| Entorhinal cortex | 1.99 (0.72) | 1.52 (0.43) | 0.034* | 3.18 (1.18) | 2.69 (0.54) | 0.144 |
| Parahippocampal gyrus | 1.96 (0.69) | 1.58 (0.33) | 0.052 | 3.26 (1.13) | 2.86 (0.44) | 0.199 |
| Lateral temporal cortex | 2.43 (0.81) | 2.03 (0.31) | 0.075 | 4.24 (1.34) | 3.78 (0.45) | 0.204 |
| Lateral parietal cortex | 2.32 (0.72) | 1.97 (0.31) | 0.091 | 4.44 (1.26) | 4.01 (0.52) | 0.211 |
| Posterior cingulum | 1.65 (0.64) | 1.42 (0.30) | 0.219 | 3.23 (1.05) | 3.01 (0.45) | 0.448 |
| Precuneus | 2.15 (0.66) | 1.82 (0.27) | 0.079 | 4.08 (1.16) | 3.71 (0.47) | 0.249 |
| Occipital cortex | 2.02 (0.59) | 1.77 (0.25) | 0.120 | 3.82 (1.03) | 3.57 (0.41) | 0.388 |
| Caudate | 2.17 (0.86) | 1.98 (0.42) | 0.439 | 3.41 (1.26) | 3.14 (0.46) | 0.427 |
| Putamen | 2.79 (0.91) | 2.57 (0.35) | 0.381 | 4.44 (1.37) | 4.19 (0.64) | 0.514 |
| Pallidum | 0.96 (0.41) | 0.81 (0.42) | 0.312 | 2.50 (1.18) | 2.30 (0.83) | 0.599 |
| Thalamus | 1.38 (0.61) | 1.12 (0.27) | 0.118 | 2.40 (0.91) | 2.04 (0.41) | 0.162 |
- Data are mean (SD). BPND binding potential of [18F]FPEB in regions of interest, CN cognitively normal (n = 15), AD Alzheimer’s disease (n = 16). p values are for post hoc two-tailed, unpaired t tests (uncorrected for multiplicity) performed after a linear mixed model analysis of BPND in multiple regions (within-subject factor) between CN and AD diagnostic groups
