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Table 3 mGluR5 binding ([18F]FPEB BPND) in brain regions of interest

From: PET imaging of mGluR5 in Alzheimer’s disease

  BPND—gray matter masked BPND—partial volume corrected
CN, mean (SD) AD, mean (SD) p CN, mean (SD) AD, mean (SD) p
Primary region
 Hippocampus 1.78 (0.61) 1.30 (0.33) 0.011* 2.69 (0.88) 2.19 (0.45) 0.0499*
 Composite association cortex 2.38 (0.76) 2.04 (0.29) 0.111 4.39 (1.30) 3.99 (0.47) 0.258
Exploratory regions
 Prefrontal cortex 2.43 (0.78) 2.15 (0.29) 0.197 4.48 (1.34) 4.10 (0.49) 0.310
 Entorhinal cortex 1.99 (0.72) 1.52 (0.43) 0.034* 3.18 (1.18) 2.69 (0.54) 0.144
 Parahippocampal gyrus 1.96 (0.69) 1.58 (0.33) 0.052 3.26 (1.13) 2.86 (0.44) 0.199
 Lateral temporal cortex 2.43 (0.81) 2.03 (0.31) 0.075 4.24 (1.34) 3.78 (0.45) 0.204
 Lateral parietal cortex 2.32 (0.72) 1.97 (0.31) 0.091 4.44 (1.26) 4.01 (0.52) 0.211
 Posterior cingulum 1.65 (0.64) 1.42 (0.30) 0.219 3.23 (1.05) 3.01 (0.45) 0.448
 Precuneus 2.15 (0.66) 1.82 (0.27) 0.079 4.08 (1.16) 3.71 (0.47) 0.249
 Occipital cortex 2.02 (0.59) 1.77 (0.25) 0.120 3.82 (1.03) 3.57 (0.41) 0.388
 Caudate 2.17 (0.86) 1.98 (0.42) 0.439 3.41 (1.26) 3.14 (0.46) 0.427
 Putamen 2.79 (0.91) 2.57 (0.35) 0.381 4.44 (1.37) 4.19 (0.64) 0.514
 Pallidum 0.96 (0.41) 0.81 (0.42) 0.312 2.50 (1.18) 2.30 (0.83) 0.599
 Thalamus 1.38 (0.61) 1.12 (0.27) 0.118 2.40 (0.91) 2.04 (0.41) 0.162
  1. Data are mean (SD). BPND binding potential of [18F]FPEB in regions of interest, CN cognitively normal (n = 15), AD Alzheimer’s disease (n = 16). p values are for post hoc two-tailed, unpaired t tests (uncorrected for multiplicity) performed after a linear mixed model analysis of BPND in multiple regions (within-subject factor) between CN and AD diagnostic groups