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Table 2 mGluR5 binding ([18F]FPEB BPND) in exploratory brain regions of interest

From: PET imaging of mGluR5 in Alzheimer’s disease

Exploratory regions

Cognitively normal

Alzheimer’s disease

p value

Mean BPND (SD)

Mean BPND (SD)

Prefrontal cortex

1.89 (0.65)

1.64 (0.25)

0.155

Entorhinal cortex

1.62 (0.46)

1.07 (0.45)

0.002*

Parahippocampal gyrus

1.52 (0.48)

1.13 (0.32)

0.012*

Lateral temporal cortex

1.94 (0.64)

1.59 (0.27)

0.060

Lateral parietal cortex

1.80 (0.59)

1.50 (0.29)

0.077

Posterior cingulum

0.99 (0.61)

0.79 (0.25)

0.230

Precuneus

1.77 (0.57)

1.50 (0.26)

0.094

Occipital cortex

1.67 (0.53)

1.44 (0.21)

0.113

Caudate

1.26 (0.72)

1.07 (0.51)

0.391

Putamen

2.16 (0.77)

1.96 (0.30)

0.326

Thalamus

0.90 (0.50)

0.64 (0.25)

0.080

  1. Data are mean (SD). BPND binding potential of [18F]FPEB in regions of interest. Cognitively normal (n = 15), Alzheimer’s disease (n = 16). p values are for post hoc two-tailed, unpaired t tests (uncorrected for multiplicity) performed after a linear mixed model analysis of BPND in multiple regions (within-subject factor) between CN and AD diagnostic groups
  2. *p < .05