Skip to main content

Table 2 mGluR5 binding ([18F]FPEB BPND) in exploratory brain regions of interest

From: PET imaging of mGluR5 in Alzheimer’s disease

Exploratory regions Cognitively normal Alzheimer’s disease p value
Mean BPND (SD) Mean BPND (SD)
Prefrontal cortex 1.89 (0.65) 1.64 (0.25) 0.155
Entorhinal cortex 1.62 (0.46) 1.07 (0.45) 0.002*
Parahippocampal gyrus 1.52 (0.48) 1.13 (0.32) 0.012*
Lateral temporal cortex 1.94 (0.64) 1.59 (0.27) 0.060
Lateral parietal cortex 1.80 (0.59) 1.50 (0.29) 0.077
Posterior cingulum 0.99 (0.61) 0.79 (0.25) 0.230
Precuneus 1.77 (0.57) 1.50 (0.26) 0.094
Occipital cortex 1.67 (0.53) 1.44 (0.21) 0.113
Caudate 1.26 (0.72) 1.07 (0.51) 0.391
Putamen 2.16 (0.77) 1.96 (0.30) 0.326
Thalamus 0.90 (0.50) 0.64 (0.25) 0.080
  1. Data are mean (SD). BPND binding potential of [18F]FPEB in regions of interest. Cognitively normal (n = 15), Alzheimer’s disease (n = 16). p values are for post hoc two-tailed, unpaired t tests (uncorrected for multiplicity) performed after a linear mixed model analysis of BPND in multiple regions (within-subject factor) between CN and AD diagnostic groups
  2. *p < .05