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Table 2 mGluR5 binding ([18F]FPEB BPND) in exploratory brain regions of interest

From: PET imaging of mGluR5 in Alzheimer’s disease

Exploratory regionsCognitively normalAlzheimer’s diseasep value
Mean BPND (SD)Mean BPND (SD)
Prefrontal cortex1.89 (0.65)1.64 (0.25)0.155
Entorhinal cortex1.62 (0.46)1.07 (0.45)0.002*
Parahippocampal gyrus1.52 (0.48)1.13 (0.32)0.012*
Lateral temporal cortex1.94 (0.64)1.59 (0.27)0.060
Lateral parietal cortex1.80 (0.59)1.50 (0.29)0.077
Posterior cingulum0.99 (0.61)0.79 (0.25)0.230
Precuneus1.77 (0.57)1.50 (0.26)0.094
Occipital cortex1.67 (0.53)1.44 (0.21)0.113
Caudate1.26 (0.72)1.07 (0.51)0.391
Putamen2.16 (0.77)1.96 (0.30)0.326
Thalamus0.90 (0.50)0.64 (0.25)0.080
  1. Data are mean (SD). BPND binding potential of [18F]FPEB in regions of interest. Cognitively normal (n = 15), Alzheimer’s disease (n = 16). p values are for post hoc two-tailed, unpaired t tests (uncorrected for multiplicity) performed after a linear mixed model analysis of BPND in multiple regions (within-subject factor) between CN and AD diagnostic groups
  2. *p < .05