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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy

Fig. 2

Chronic JM4 treatment rescued behavioral abnormalities in PS19 mice. a JM4-treated PS19 mice at 7 months of age took less time to find the target hole than PBS sham-treated group in the Barnes maze test (*p < 0.05, two-tailed unpaired t test). b PBS sham-treated PS19 mice traveled a longer distance to find the target hole in the Barnes maze test (*p < 0.05, two-tailed unpaired t test). c PS19 mice spent more time on the open arm than the wild-type mice suggesting PS19 mice have less anxiety-like behavior when compared to wild-type mice (***p < 0.001, PBS sham-treated PS 19 mice vs. wild-type mice, one-way ANOVA followed by Tukey’s multiple comparison test). Chronic JM4 treatment significantly reduced this behavioral abnormality in PS19 mice (*p < 0.05, PBS sham-treated PS19 mice vs. JM4-treated PS19 mice). d There was no significant difference in total distance traveled among PBS sham-treated PS19 mice, JM4-treated PS19 mice, and wild-type control (ns, not significant; one-way ANOVA followed by Tukey’s multiple comparison test)

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