Fig. 1

PSEN1 E280A mutation carriers show greater rates of tau and Aβ increase compared to non-carriers. Upper, dot plots of Aβ (a, left) and tau (b, right) PET change rates, expressed as annualized change in PiB DVR and FTP SUVR respectively, in all regions of interest (ROIs). Dots are color-encoded by carrier and cognitive status according to inset legend (lower right). Primary ROIs for each modality are shown above horizontal dashed line; other ROIs below the dashed line are ordered from top to bottom by highest to lowest mean change rate within all carriers. Neocortical Aβ change rates were normalized to the Centiloid scale, shown at top (†); note that the Centiloid scale does not apply to any other ROI. Adjusted p values for group difference (Mann-Whitney, Bonferroni-Holms correction) between all carriers and non-carriers are given for primary ROIs (*p < 0.05 after multiple comparisons correction); other regions are shown for comparison with other studies but were not included in statistical analyses. EAOT = aggregate (unweighted average) of bilateral entorhinal, amygdala, occipital, and inferior temporal ROIs (Mishra et al. [33]); TempMeta = aggregate of bilateral entorhinal, amygdala, parahippocampal, fusiform, inferior and middle temporal (Jack et al. [20]). Lower, Surface visualization of mean rates of Aβ (c, left) and tau (d, right) change within all carriers, expressed as annualized change in PiB DVR and FTP SUVR, respectively, according to the color bar