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Table 4 Sensitivity analysis—estimated relative risk (RR) for the risk of dropout for participants in North America

From: Recruitment and retention of participant and study partner dyads in two multinational Alzheimer’s disease registration trials

 

Subjects (N = 2603)

Events (N = 928)

Deaths (N = 45)

Unadjusted RR

Unadj. p value

Adjusted RR

Adj. p value

Partner typea

    

0.595

 

0.53

 Spouse

720

268

13

1

1

 Adult child

171

69

6

1.13 (0.86, 1.48)

0.374

0.81 (0.49, 1.36)

0.427

 Other

80

32

0

1.12 (0.78, 1.62)

0.532

1.06 (0.66, 1.72)

0.802

Participant age (per 10 years)

971

369

19

1.47 (1.30, 1.66)

< .001

1.47 (1.23, 1.75)

< .001

Education (years)

971

369

19

0.95 (0.92, 0.98)

0.001

0.97 (0.93, 1.00)

0.034

Partner age (per 10 years)

971

369

19

1.12 (1.02, 1.23)

0.021

0.97 (0.82, 1.14)

0.699

Baseline test scores

 Mini-Mental State Exam

971

369

19

0.94 (0.91, 0.97)

< .001

0.94 (0.91, 0.97)

< .001

 Hachinski Score

971

369

19

1.12 (1.00, 1.26)

0.049

1.04 (0.92, 1.19)

0.513

 Geriatric Depression Scale

971

369

19

1.08 (1.01, 1.15)

0.035

1.08 (1.01, 1.16)

0.031

Participant sex

 Female

504

188

8

1

1

 Male

467

181

11

1.02 (0.83, 1.26)

0.821

1.02 (0.73, 1.42)

0.903

Partner sex

 Female

600

239

13

1

1

 Male

371

130

6

0.86 (0.69, 1.06)

0.162

0.88 (0.64, 1.23)

0.469

Partner employed

 No

649

270

13

1

1

 Yes

322

99

6

0.69 (0.54, 0.86)

0.001

0.75 (0.57, 0.99)

0.046

APOE carrier

 No

318

127

7

1

1

 Yes

653

242

12

0.88 (0.71, 1.10)

0.263

0.96 (0.76, 1.22)

0.76

Race/ethnicity

 White

922

346

16

1

1

 Asian

13

6

0

1.13 (0.54, 2.38)

0.741

1.15 (0.50, 2.63)

0.743

 Hispanic

16

8

3

1.30 (0.65, 2.60)

0.452

1.07 (0.52, 2.19)

0.861

 African American/Black

20

9

0

1.43 (0.70, 2.93)

0.325

1.18 (0.52, 2.68)

0.69

  1. aPartial likelihood ratio test of the null hypothesis that there is no difference in risk of dropping out by study partner (SP) type