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Table 2 Estimated relative risk (RR) for the risk of dropout

From: Recruitment and retention of participant and study partner dyads in two multinational Alzheimer’s disease registration trials

 

Subjects (N = 2603)

Events (N = 928)

Deaths (N = 45)

Unadjusted RR

Unadj. p value

Adjusted RR

Adj. p value

Partner typea

    

0.027

 

0.928

 Spouse

1721

597

28

1

1

 Adult child

658

251

16

1.23 (1.06, 1.42)

0.007

1.06 (0.79, 1.43)

0.698

 Other

224

80

1

1.08 (0.86, 1.36)

0.524

1.03 (0.75, 1.40)

0.863

Participant age (per 10 years)

2603

928

45

1.41 (1.29, 1.53)

< .001

1.41 (1.26, 1.58)

< .001

Education (years)

2603

928

45

0.98 (0.96, 1.00)

0.011

0.99 (0.97, 1.01)

0.165

Partner age (per 10 years)

2603

928

45

1.04 (0.99, 1.09)

0.15

1.02 (0.93, 1.13)

0.645

Baseline test scores

 Mini-Mental State Exam

2603

928

45

0.94 (0.92, 0.96)

< .001

0.95 (0.92, 0.97)

< .001

 Hachinski Score

2603

928

45

1.14 (1.06, 1.22)

< .001

1.04 (0.96, 1.12)

0.336

 Geriatric Depression Scale

2603

928

45

1.09 (1.05, 1.13)

< .001

1.09 (1.05, 1.14)

< .001

Participant sex

 Female

1437

493

19

1

1

 Male

1166

435

26

1.07 (0.94, 1.22)

0.281

1.26 (1.05, 1.51)

0.013

Partner sex

 Female

1602

588

26

1

1

 Male

1001

340

19

0.91 (0.80, 1.04)

0.172

1.10 (0.92, 1.32)

0.293

Partner employed

 No

1652

615

27

1

1

 Yes

951

313

18

0.88 (0.77, 1.01)

0.06

0.93 (0.79, 1.09)

0.373

APOE carrier

 No

903

333

20

1

1

 Yes

1700

595

25

0.94 (0.82, 1.08)

0.396

1.00 (0.87, 1.15)

0.993

Region

 North America

971

369

19

1

1

 South America/Mexico

201

81

6

1.24 (0.98, 1.57)

0.08

1.03 (0.79, 1.34)

0.828

 Eastern Europe/Russia

286

133

2

1.50 (1.24, 1.83)

< .001

1.44 (1.16, 1.80)

0.001

 Western Europe/Israel

543

167

7

0.78 (0.65, 0.94)

0.007

0.82 (0.67, 0.99)

0.044

 Australia/South Africa

151

57

6

0.96 (0.73, 1.28)

0.803

0.97 (0.73, 1.29)

0.823

 Asia

200

62

2

1.07 (0.82, 1.40)

0.608

1.02 (0.77, 1.35)

0.899

 Japan

251

59

3

0.60 (0.45, 0.79)

< .001

0.58 (0.44, 0.78)

< .001

  1. aPartial likelihood ratio test of the null hypothesis that there is no difference in risk of dropping out by study partner (SP) type