Subjects (N = 2603) | Events (N = 928) | Deaths (N = 45) | Unadjusted RR | Unadj. p value | Adjusted RR | Adj. p value | |
---|---|---|---|---|---|---|---|
Partner typea | 0.027 | 0.928 | |||||
Spouse | 1721 | 597 | 28 | 1 | – | 1 | – |
Adult child | 658 | 251 | 16 | 1.23 (1.06, 1.42) | 0.007 | 1.06 (0.79, 1.43) | 0.698 |
Other | 224 | 80 | 1 | 1.08 (0.86, 1.36) | 0.524 | 1.03 (0.75, 1.40) | 0.863 |
Participant age (per 10 years) | 2603 | 928 | 45 | 1.41 (1.29, 1.53) | < .001 | 1.41 (1.26, 1.58) | < .001 |
Education (years) | 2603 | 928 | 45 | 0.98 (0.96, 1.00) | 0.011 | 0.99 (0.97, 1.01) | 0.165 |
Partner age (per 10 years) | 2603 | 928 | 45 | 1.04 (0.99, 1.09) | 0.15 | 1.02 (0.93, 1.13) | 0.645 |
Baseline test scores | |||||||
Mini-Mental State Exam | 2603 | 928 | 45 | 0.94 (0.92, 0.96) | < .001 | 0.95 (0.92, 0.97) | < .001 |
Hachinski Score | 2603 | 928 | 45 | 1.14 (1.06, 1.22) | < .001 | 1.04 (0.96, 1.12) | 0.336 |
Geriatric Depression Scale | 2603 | 928 | 45 | 1.09 (1.05, 1.13) | < .001 | 1.09 (1.05, 1.14) | < .001 |
Participant sex | |||||||
Female | 1437 | 493 | 19 | 1 | – | 1 | – |
Male | 1166 | 435 | 26 | 1.07 (0.94, 1.22) | 0.281 | 1.26 (1.05, 1.51) | 0.013 |
Partner sex | |||||||
Female | 1602 | 588 | 26 | 1 | – | 1 | – |
Male | 1001 | 340 | 19 | 0.91 (0.80, 1.04) | 0.172 | 1.10 (0.92, 1.32) | 0.293 |
Partner employed | |||||||
No | 1652 | 615 | 27 | 1 | – | 1 | – |
Yes | 951 | 313 | 18 | 0.88 (0.77, 1.01) | 0.06 | 0.93 (0.79, 1.09) | 0.373 |
APOE carrier | |||||||
No | 903 | 333 | 20 | 1 | – | 1 | – |
Yes | 1700 | 595 | 25 | 0.94 (0.82, 1.08) | 0.396 | 1.00 (0.87, 1.15) | 0.993 |
Region | |||||||
North America | 971 | 369 | 19 | 1 | – | 1 | – |
South America/Mexico | 201 | 81 | 6 | 1.24 (0.98, 1.57) | 0.08 | 1.03 (0.79, 1.34) | 0.828 |
Eastern Europe/Russia | 286 | 133 | 2 | 1.50 (1.24, 1.83) | < .001 | 1.44 (1.16, 1.80) | 0.001 |
Western Europe/Israel | 543 | 167 | 7 | 0.78 (0.65, 0.94) | 0.007 | 0.82 (0.67, 0.99) | 0.044 |
Australia/South Africa | 151 | 57 | 6 | 0.96 (0.73, 1.28) | 0.803 | 0.97 (0.73, 1.29) | 0.823 |
Asia | 200 | 62 | 2 | 1.07 (0.82, 1.40) | 0.608 | 1.02 (0.77, 1.35) | 0.899 |
Japan | 251 | 59 | 3 | 0.60 (0.45, 0.79) | < .001 | 0.58 (0.44, 0.78) | < .001 |