Fig. 4
From: Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice
Immunohistochemical analysis of Aβ burden in cortex of APP/PS1 mice. a Representative images of 6E10-labeled Aβ burden in the ipsilateral and contralateral cortices of APP/PS1 mice. Scale bars, 200 μm. b, c Quantification of percent area covered by 6E10 staining in the ipsilateral cortex (b) and contralateral cortex (c) of the APP/PS1 mice. Data were analyzed by one-way ANOVA followed by the Bonferroni post hoc test. Values are presented as mean±SEM. n = 5 per group. *P < 0.05 vs. ctr+veh group; #P < 0.05 vs. tau+veh group; &P < 0.05 vs. ctr+met group