Fig. 4
Case study—drug repurposing. Sildenafil and pioglitazone are used as examples to demonstrate how to use AlzGPS for drug repurposing. a Basic information for sildenafil. b Network proximity results for sildenafil. c Literature evidence for sildenafil. d Inferred mechanism-of-action for sildenafil targeting the “V1 AD-seed” data set, which contains 144 high-quality literature-based Alzheimer’s disease (AD) endophenotype genes. e Basic information for pioglitazone. f Network proximity results for pioglitazone. g Five studies were found that were related to treating AD with pioglitazone. h Inferred mechanism-of-action for pioglitazone targeting the “V4 AD-inferred-GWAS-risk-genes” data set which contains 103 high-confidence AD risk genes identified using genome-wide association studies