Fig. 3

Case study—target identification. Four genes, MAPT (a), INPP5D (b), APOE (c), and BACE1 (d), are used as examples to show the gene page. On the gene page, we show a summary of several statistics of the gene in AlzGPS, including the number of drugs that can target it, number of data sets of omics in which the target/protein coding gene is differentially expressed, number of genetic records, and the brain expression specificity. Detailed information can be loaded by clicking corresponding buttons. Examples of detailed differential expression results and genetic records are shown for these four genes. In addition, a brain-specific neighborhood network is available that centers around the gene-of-interest and shows the targetability of its neighborhood