TY - STD TI - 2020 Alzheimer’s disease facts and figures. Alzheimers Dement. 2020;16(3):391–460. ID - ref1 ER - TY - JOUR AU - Long, J. M. AU - Holtzman, D. M. PY - 2019 DA - 2019// TI - Alzheimer disease: an update on pathobiology and treatment strategies JO - Cell. VL - 179 UR - https://doi.org/10.1016/j.cell.2019.09.001 DO - 10.1016/j.cell.2019.09.001 ID - Long2019 ER - TY - JOUR AU - Masters, C. L. AU - Bateman, R. AU - Blennow, K. AU - Rowe, C. C. AU - Sperling, R. A. AU - Cummings, J. L. PY - 2015 DA - 2015// TI - Alzheimer’s disease JO - Nat Rev Dis Primers VL - 1 UR - https://doi.org/10.1038/nrdp.2015.56 DO - 10.1038/nrdp.2015.56 ID - Masters2015 ER - TY - JOUR AU - Kodamullil, A. T. AU - Zekri, F. AU - Sood, M. AU - Hengerer, B. AU - Canard, L. AU - McHale, D. PY - 2017 DA - 2017// TI - Trial watch: tracing investment in drug development for Alzheimer disease JO - Nat Rev Drug Discov VL - 16 UR - https://doi.org/10.1038/nrd.2017.169 DO - 10.1038/nrd.2017.169 ID - Kodamullil2017 ER - TY - JOUR AU - Alteri, E. AU - Guizzaro, L. PY - 2018 DA - 2018// TI - Be open about drug failures to speed up research JO - Nature. VL - 563 UR - https://doi.org/10.1038/d41586-018-07352-7 DO - 10.1038/d41586-018-07352-7 ID - Alteri2018 ER - TY - JOUR AU - Fang, J. AU - Pieper, A. A. AU - Nussinov, R. AU - Lee, G. AU - Bekris, L. AU - Leverenz, J. B. PY - 2020 DA - 2020// TI - Harnessing endophenotypes and network medicine for Alzheimer’s drug repurposing JO - Med Res Rev VL - 40 UR - https://doi.org/10.1002/med.21709 DO - 10.1002/med.21709 ID - Fang2020 ER - TY - JOUR AU - Cummings, J. AU - Feldman, H. H. AU - Scheltens, P. PY - 2019 DA - 2019// TI - The “rights” of precision drug development for Alzheimer’s disease JO - Alzheimers Res Ther VL - 11 UR - https://doi.org/10.1186/s13195-019-0529-5 DO - 10.1186/s13195-019-0529-5 ID - Cummings2019 ER - TY - JOUR AU - Keren-Shaul, H. AU - Spinrad, A. AU - Weiner, A. AU - Matcovitch-Natan, O. AU - Dvir-Szternfeld, R. AU - Ulland, T. K. PY - 2017 DA - 2017// TI - A unique microglia type associated with restricting development of Alzheimer’s disease JO - Cell. VL - 169 UR - https://doi.org/10.1016/j.cell.2017.05.018 DO - 10.1016/j.cell.2017.05.018 ID - Keren-Shaul2017 ER - TY - JOUR AU - Lambert, J. C. AU - Ibrahim-Verbaas, C. A. AU - Harold, D. AU - Naj, A. C. AU - Sims, R. AU - Bellenguez, C. PY - 2013 DA - 2013// TI - Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease JO - Nat Genet VL - 45 UR - https://doi.org/10.1038/ng.2802 DO - 10.1038/ng.2802 ID - Lambert2013 ER - TY - JOUR AU - Bai, B. AU - Wang, X. AU - Li, Y. AU - Chen, P. C. AU - Yu, K. AU - Dey, K. K. PY - 2020 DA - 2020// TI - Deep multilayer brain proteomics identifies molecular networks in Alzheimer’s disease progression JO - Neuron. VL - 105 UR - https://doi.org/10.1016/j.neuron.2019.12.015 DO - 10.1016/j.neuron.2019.12.015 ID - Bai2020 ER - TY - JOUR AU - Cheng, F. AU - Lu, W. AU - Liu, C. AU - Fang, J. AU - Hou, Y. AU - Handy, D. E. PY - 2019 DA - 2019// TI - A genome-wide positioning systems network algorithm for in silico drug repurposing JO - Nat Commun VL - 10 UR - https://doi.org/10.1038/s41467-019-10744-6 DO - 10.1038/s41467-019-10744-6 ID - Cheng2019 ER - TY - JOUR AU - Cheng, F. AU - Desai, R. J. AU - Handy, D. E. AU - Wang, R. AU - Schneeweiss, S. AU - Barabasi, A. L. PY - 2018 DA - 2018// TI - Network-based approach to prediction and population-based validation of in silico drug repurposing JO - Nat Commun VL - 9 UR - https://doi.org/10.1038/s41467-018-05116-5 DO - 10.1038/s41467-018-05116-5 ID - Cheng2018 ER - TY - JOUR AU - Wang, Q. AU - Chen, R. AU - Cheng, F. AU - Wei, Q. AU - Ji, Y. AU - Yang, H. PY - 2019 DA - 2019// TI - A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data JO - Nat Neurosci VL - 22 UR - https://doi.org/10.1038/s41593-019-0382-7 DO - 10.1038/s41593-019-0382-7 ID - Wang2019 ER - TY - STD TI - Fang J, Zhang P, Wang Q, Zhou Y, Chiang WC, Cheng R, et al. Network-based translation of GWAS findings to pathobiology and drug repurposing for Alzheimer’s disease. medRxiv. 2020:2020.01.15.20017160. https://doi.org/10.1101/2020.01.15.20017160. ID - ref14 ER - TY - JOUR AU - Zhou, Y. AU - Hou, Y. AU - Shen, J. AU - Huang, Y. AU - Martin, W. AU - Cheng, F. PY - 2020 DA - 2020// TI - Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 JO - Cell Discov VL - 6 UR - https://doi.org/10.1038/s41421-020-0153-3 DO - 10.1038/s41421-020-0153-3 ID - Zhou2020 ER - TY - JOUR AU - Zhou, Y. AU - Wang, F. AU - Tang, J. AU - Nussinov, R. AU - Cheng, F. PY - 2020 DA - 2020// TI - Artificial intelligence in COVID-19 drug repurposing JO - Lancet Digit Health VL - 2 UR - https://doi.org/10.1016/S2589-7500(20)30192-8 DO - 10.1016/S2589-7500(20)30192-8 ID - Zhou2020 ER - TY - JOUR AU - Edgar, R. AU - Domrachev, M. AU - Lash, A. E. PY - 2002 DA - 2002// TI - Gene Expression Omnibus: NCBI gene expression and hybridization array data repository JO - Nucleic Acids Res VL - 30 UR - https://doi.org/10.1093/nar/30.1.207 DO - 10.1093/nar/30.1.207 ID - Edgar2002 ER - TY - JOUR AU - Barrett, T. AU - Wilhite, S. E. AU - Ledoux, P. AU - Evangelista, C. AU - Kim, I. F. AU - Tomashevsky, M. PY - 2013 DA - 2013// TI - NCBI GEO: archive for functional genomics data sets--update JO - Nucleic Acids Res VL - 41 ID - Barrett2013 ER - TY - JOUR AU - Ritchie, M. E. AU - Phipson, B. AU - Wu, D. AU - Hu, Y. AU - Law, C. W. AU - Shi, W. PY - 2015 DA - 2015// TI - limma powers differential expression analyses for RNA-sequencing and microarray studies JO - Nucleic Acids Res VL - 43 UR - https://doi.org/10.1093/nar/gkv007 DO - 10.1093/nar/gkv007 ID - Ritchie2015 ER - TY - JOUR AU - Braschi, B. AU - Denny, P. AU - Gray, K. AU - Jones, T. AU - Seal, R. AU - Tweedie, S. PY - 2019 DA - 2019// TI - Genenames.org: the HGNC and VGNC resources in 2019 JO - Nucleic Acids Res VL - 47 UR - https://doi.org/10.1093/nar/gky930 DO - 10.1093/nar/gky930 ID - Braschi2019 ER - TY - JOUR AU - Buniello, A. AU - MacArthur, J. A. L. AU - Cerezo, M. AU - Harris, L. W. AU - Hayhurst, J. AU - Malangone, C. PY - 2019 DA - 2019// TI - The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 JO - Nucleic Acids Res VL - 47 UR - https://doi.org/10.1093/nar/gky1120 DO - 10.1093/nar/gky1120 ID - Buniello2019 ER - TY - JOUR AU - Law, V. AU - Knox, C. AU - Djoumbou, Y. AU - Jewison, T. AU - Guo, A. C. AU - Liu, Y. PY - 2014 DA - 2014// TI - DrugBank 4.0: shedding new light on drug metabolism JO - Nucleic Acids Res VL - 42 UR - https://doi.org/10.1093/nar/gkt1068 DO - 10.1093/nar/gkt1068 ID - Law2014 ER - TY - JOUR AU - Cheng, F. AU - Li, W. AU - Zhou, Y. AU - Shen, J. AU - Wu, Z. AU - Liu, G. PY - 2012 DA - 2012// TI - admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties JO - J Chem Inf Model VL - 52 UR - https://doi.org/10.1021/ci300367a DO - 10.1021/ci300367a ID - Cheng2012 ER - TY - JOUR AU - Cheng, F. AU - Li, W. AU - Zhou, Y. AU - Shen, J. AU - Wu, Z. AU - Liu, G. PY - 2019 DA - 2019// TI - Correction to “admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties” JO - J Chem Inf Model VL - 59 UR - https://doi.org/10.1021/acs.jcim.9b00969 DO - 10.1021/acs.jcim.9b00969 ID - Cheng2019 ER - TY - JOUR AU - Yang, H. AU - Qin, C. AU - Li, Y. H. AU - Tao, L. AU - Zhou, J. AU - Yu, C. Y. PY - 2016 DA - 2016// TI - Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information JO - Nucleic Acids Res VL - 44 UR - https://doi.org/10.1093/nar/gkv1230 DO - 10.1093/nar/gkv1230 ID - Yang2016 ER - TY - JOUR AU - Gaulton, A. AU - Bellis, L. J. AU - Bento, A. P. AU - Chambers, J. AU - Davies, M. AU - Hersey, A. PY - 2012 DA - 2012// TI - ChEMBL: a large-scale bioactivity database for drug discovery JO - Nucleic Acids Res VL - 40 UR - https://doi.org/10.1093/nar/gkr777 DO - 10.1093/nar/gkr777 ID - Gaulton2012 ER - TY - JOUR AU - Liu, T. AU - Lin, Y. AU - Wen, X. AU - Jorissen, R. N. AU - Gilson, M. K. PY - 2007 DA - 2007// TI - BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities JO - Nucleic Acids Res VL - 35 UR - https://doi.org/10.1093/nar/gkl999 DO - 10.1093/nar/gkl999 ID - Liu2007 ER - TY - JOUR AU - Pawson, A. J. AU - Sharman, J. L. AU - Benson, H. E. AU - Faccenda, E. AU - Alexander, S. P. AU - Buneman, O. P. PY - 2014 DA - 2014// TI - The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands JO - Nucleic Acids Res VL - 42 UR - https://doi.org/10.1093/nar/gkt1143 DO - 10.1093/nar/gkt1143 ID - Pawson2014 ER - TY - JOUR AU - Cummings, J. AU - Lee, G. AU - Ritter, A. AU - Zhong, K. PY - 2018 DA - 2018// TI - Alzheimer’s disease drug development pipeline: 2018 JO - Alzheimers Dement (N Y). VL - 4 UR - https://doi.org/10.1016/j.trci.2018.03.009 DO - 10.1016/j.trci.2018.03.009 ID - Cummings2018 ER - TY - JOUR AU - Cummings, J. AU - Lee, G. AU - Ritter, A. AU - Sabbagh, M. AU - Zhong, K. PY - 2019 DA - 2019// TI - Alzheimer’s disease drug development pipeline: 2019 JO - Alzheimers Dement (N Y) VL - 5 UR - https://doi.org/10.1016/j.trci.2019.05.008 DO - 10.1016/j.trci.2019.05.008 ID - Cummings2019 ER - TY - JOUR AU - Cheng, F. AU - Kovacs, I. A. AU - Barabasi, A. L. PY - 2019 DA - 2019// TI - Network-based prediction of drug combinations JO - Nat Commun VL - 10 UR - https://doi.org/10.1038/s41467-019-09186-x DO - 10.1038/s41467-019-09186-x ID - Cheng2019 ER - TY - JOUR AU - Smith, I. N. AU - Thacker, S. AU - Seyfi, M. AU - Cheng, F. AU - Eng, C. PY - 2019 DA - 2019// TI - Conformational dynamics and allosteric regulation landscapes of germline PTEN mutations associated with autism compared to those associated with cancer JO - Am J Hum Genet VL - 104 UR - https://doi.org/10.1016/j.ajhg.2019.03.009 DO - 10.1016/j.ajhg.2019.03.009 ID - Smith2019 ER - TY - BOOK AU - Hagberg, A. AU - Schult, D. AU - Swart, P. PY - 2008 DA - 2008// TI - Exploring network structure, dynamics, and function using NetworkX. Proceedings of the 7th Python in Science Conference (SciPy2008) ID - Hagberg2008 ER - TY - JOUR AU - Franz, M. AU - Lopes, C. T. AU - Huck, G. AU - Dong, Y. AU - Sumer, O. AU - Bader, G. D. PY - 2016 DA - 2016// TI - Cytoscape.js: a graph theory library for visualisation and analysis JO - Bioinformatics. VL - 32 ID - Franz2016 ER - TY - JOUR AU - Kosik, K. S. AU - Joachim, C. L. AU - Selkoe, D. J. PY - 1986 DA - 1986// TI - Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease JO - Proc Natl Acad Sci U S A VL - 83 UR - https://doi.org/10.1073/pnas.83.11.4044 DO - 10.1073/pnas.83.11.4044 ID - Kosik1986 ER - TY - JOUR AU - Goedert, M. AU - Wischik, C. M. AU - Crowther, R. A. AU - Walker, J. E. AU - Klug, A. PY - 1988 DA - 1988// TI - Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau JO - Proc Natl Acad Sci U S A VL - 85 UR - https://doi.org/10.1073/pnas.85.11.4051 DO - 10.1073/pnas.85.11.4051 ID - Goedert1988 ER - TY - JOUR AU - Kovacs, G. G. PY - 2015 DA - 2015// TI - Invited review: neuropathology of tauopathies: principles and practice JO - Neuropathol Appl Neurobiol VL - 41 UR - https://doi.org/10.1111/nan.12208 DO - 10.1111/nan.12208 ID - Kovacs2015 ER - TY - JOUR AU - Jing, H. AU - Zhu, J. X. AU - Wang, H. F. AU - Zhang, W. AU - Zheng, Z. J. AU - Kong, L. L. PY - 2016 DA - 2016// TI - INPP5D rs35349669 polymorphism with late-onset Alzheimer’s disease: a replication study and meta-analysis JO - Oncotarget. VL - 7 UR - https://doi.org/10.18632/oncotarget.12648 DO - 10.18632/oncotarget.12648 ID - Jing2016 ER - TY - JOUR AU - Yao, X. AU - Risacher, S. L. AU - Nho, K. AU - Saykin, A. J. AU - Wang, Z. AU - Shen, L. PY - 2019 DA - 2019// TI - Targeted genetic analysis of cerebral blood flow imaging phenotypes implicates the INPP5D gene JO - Neurobiol Aging VL - 81 UR - https://doi.org/10.1016/j.neurobiolaging.2019.06.003 DO - 10.1016/j.neurobiolaging.2019.06.003 ID - Yao2019 ER - TY - JOUR AU - Mahley, R. W. AU - Rall, S. C. PY - 2000 DA - 2000// TI - Apolipoprotein E: far more than a lipid transport protein JO - Annu Rev Genomics Hum Genet VL - 1 UR - https://doi.org/10.1146/annurev.genom.1.1.507 DO - 10.1146/annurev.genom.1.1.507 ID - Mahley2000 ER - TY - JOUR AU - Liu, C. C. AU - Kanekiyo, T. AU - Xu, H. AU - Bu, G. PY - 2013 DA - 2013// TI - Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy JO - Nat Rev Neurol VL - 9 UR - https://doi.org/10.1038/nrneurol.2012.263 DO - 10.1038/nrneurol.2012.263 ID - Liu2013 ER - TY - JOUR AU - Cai, H. AU - Wang, Y. AU - McCarthy, D. AU - Wen, H. AU - Borchelt, D. R. AU - Price, D. L. PY - 2001 DA - 2001// TI - BACE1 is the major beta-secretase for generation of Abeta peptides by neurons JO - Nat Neurosci VL - 4 UR - https://doi.org/10.1038/85064 DO - 10.1038/85064 ID - Cai2001 ER - TY - JOUR AU - Venkat, P. AU - Chopp, M. AU - Zacharek, A. AU - Cui, C. AU - Landschoot-Ward, J. AU - Qian, Y. PY - 2019 DA - 2019// TI - Sildenafil treatment of vascular dementia in aged rats JO - Neurochem Int VL - 127 UR - https://doi.org/10.1016/j.neuint.2018.12.015 DO - 10.1016/j.neuint.2018.12.015 ID - Venkat2019 ER - TY - JOUR AU - Sato, T. AU - Hanyu, H. AU - Hirao, K. AU - Kanetaka, H. AU - Sakurai, H. AU - Iwamoto, T. PY - 2011 DA - 2011// TI - Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease JO - Neurobiol Aging VL - 32 UR - https://doi.org/10.1016/j.neurobiolaging.2009.10.009 DO - 10.1016/j.neurobiolaging.2009.10.009 ID - Sato2011 ER -