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Table 2 Relationships of AV45-SUVR, FDG-SUVR, and GMV with WMH volume in regions-of-interest

From: Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease

Regional WMH volume

AV45-SUVR

FDG-SUVR

GMV

r

p

r

p

r

p

i.

Global WM

.056

.517

− .300

< .001a,b

− .354

< .001a,b

Frontal WM

− .030

.724

− .035

.677

− .372

< .001a,b

Temporal WM

.002

.977

− .153

.064

− .396

< .001a,b

Occipital WM

.064

.453

− .300

< .001a,b

− .409

< .001a,b

Parietal WM

.045

.602

− .242

.003a,b

− .380

< .001a,b

ii.

Corona radiata

.026

.763

− .285

< .001a,b

− .382

< .001a,b

External capsule

.060

.485

− .097

.245

− .319

< .001a,b

Internal capsule

.056

.513

− .371

< .001a,b

− .421

< .001a,b

Optic radiation

.039

.647

− .198

.016a

− .175

.032a

iii.

Genu corpus callosum

.035

.684

− .164

.047a

− .312

< .001a,b

Body corpus callosum

.114

.184

− .256

.002a,b

− .247

.002a,b

Splenium corpus callosum

.130

.128

− .443

< .001a,b

− .442

< .001a,b

  1. SUVR standardized uptake value ratio, AV45 florbetapir, FDG fluorodeoxyglucose, GMV gray matter volume, TIV total intracranial volume, WM white matter
  2. Results of the Pearson correlation analysis, adjusted for covariates of age, sex, education, and systolic blood pressure. WMH volumes in regions-of-interest (ROIs) were adjusted for TIV and log-transformed; AV45-SUVR were also log-transformed. ROI in (i) brain lobes, (ii) WM tracts, and (iii) corpus callosum. aSignificant result at p < .05 uncorrected. bSignificant result at p < .05 Bonferroni-corrected