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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease

Fig. 1

Frequency map and results of voxel-based analyses. a WMH frequency map across the whole cohort (n = 155) thresholded at 5% used as an explicit mask in regressions analyses. b–d Relationships between AV45-SUVR (b), FDG-SUVR (c), GMV (d), and spatial WMH distribution at the voxel level (dependent variable). Topographic patterns are displayed at p < .005 uncorrected. Corresponding scatter plots visualize the respective relationships using unadjusted values for the whole cohort. Circles represent individual data points (blue = OC, green = SCD, orange = MCI, red = AD), lines indicate linear trends, gray-shaded areas indicate 95% confidence intervals. e Superposition of the three topographic patterns (b, c, and d) with blue = FDG-SUVR only, green = GMV only, orange = superposition FDG-SUVR/GMV, and red = superposition AV45-SUVR/FDG-SUVR/GMV. OC older controls, SCD participants with subjective cognitive decline, MCI patients with mild cognitive impairment, AD patients with Alzheimer’s disease, WMH white matter hyperintensities, SUVR standardized uptake value ratio, AV45 florbetapir, FDG fluorodeoxyglucose, GMV gray matter volume, TIV total intracranial volume.

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Alzheimer's Research & Therapy

ISSN: 1758-9193