From: The insulin resistance by triglyceride glucose index and risk for dementia: population-based study
TyG index quartiles | p value | ||||
---|---|---|---|---|---|
Q1 | Q2 | Q3 | Q4 | ||
TyG index | |||||
Male | < 8.32 | ≥ 8.32, < 8.70 | ≥ 8.70, < 9.12 | ≥ 9.12 | < 0.001 |
Female | < 8.05 | ≥ 8.05, < 8.41 | ≥ 8.41, < 8.79 | ≥ 8.79 | < 0.001 |
n | 2,109,016 | 2,109,379 | 2,105,801 | 2,108,850 | |
Age (years) | 40.77 ± 13.3 | 44.08 ± 13.24 | 46.48 ± 13.12 | 48.49 ± 12.95 | < 0.001 |
< 65 | 1,977,515 (93.76) | 1,934,973 (91.73) | 1,887,905 (89.65) | 1,842,996 (87.39) | |
≥ 65 | 131,501 (6.24) | 174,406 (8.27) | 217,896 (10.35) | 265,854 (12.61) | |
Sex | 0.935 | ||||
Male | 1,174,379 (55.68) | 1,173,923 (55.65) | 1,172,194 (55.66) | 1,173,998 (55.67) | |
Female | 934,637 (44.32) | 935,456 (44.35) | 933,607 (44.34) | 934,852 (44.33) | |
BMI (kg/m2) | 22.13 ± 2.79 | 23.03 ± 2.98 | 23.9 ± 3.08 | 24.95 ± 3.13 | < 0.001 |
≥ 25 kg/m2 | 310,449 (14.72) | 500,595 (23.73) | 705,893 (33.52) | 987,536 (46.83) | < 0.001 |
Waist circumference (cm) | 75.62 ± 8.29 | 78.24 ± 8.65 | 80.63 ± 8.67 | 83.49 ± 8.4 | < 0.001 |
Male ≥ 90, female ≥ 85 | 139,015 (6.59) | 257,122 (12.19) | 400,791 (19.03) | 623,333 (29.56) | < 0.001 |
Regular physical activity | 1,142,254 (54.16) | 1,111,265 (52.68) | 1,086,109 (51.58) | 1,050,834 (49.83) | < 0.001 |
Low socioeconomic status | 582,805 (27.63) | 559,430 (26.52) | 546,658 (25.96) | 542,423 (25.72) | < 0.001 |
Smoking status | < 0.001 | ||||
Non-smoker | 1,304,461 (61.85) | 1,254,610 (59.48) | 1,217,185 (57.8) | 1,164,006 (55.2) | |
Ex-smoker | 284,472 (13.49) | 296,684 (14.06) | 299,196 (14.21) | 286,796 (13.6) | |
Current smoker | 520,083 (24.66) | 558,085 (26.46) | 589,420 (27.99) | 658,048 (31.2) | |
Alcohol consumption | < 0.001 | ||||
None/mild | 1,012,048 (47.99) | 1,037,179 (49.17) | 1,051,377 (49.93) | 1,037,392 (49.19) | |
Moderate | 986,225 (46.76) | 943,026 (44.71) | 903,865 (42.92) | 868,558 (41.19) | |
Heavy | 110,743 (5.25) | 129,174 (6.12) | 150,559 (7.15) | 202,900 (9.62) | |
Systolic BP (mmHg) | 117.24 ± 13.53 | 119.95 ± 14.08 | 122.49 ± 14.43 | 126.02 ± 14.93 | < 0.001 |
Diastolic BP (mmHg) | 73.22 ± 9.35 | 75 ± 9.63 | 76.6 ± 9.77 | 78.8 ± 10.03 | < 0.001 |
Glucose (mg/dL) | 87.16 ± 10.34 | 91.38 ± 11.41 | 94.66 ± 13.1 | 102.8 ± 24.02 | < 0.001 |
Total cholesterol (mg/dL) | 177.74 ± 29.97 | 189.18 ± 31.39 | 198.18 ± 32.91 | 209.72 ± 36.07 | < 0.001 |
HDL cholesterol (mg/dL) | 60.65 ± 15.48 | 57.44 ± 16.36 | 54.52 ± 17.67 | 50.44 ± 21.93 | < 0.001 |
LDL cholesterol (mg/dL) | 105.11 ± 28.07 | 113.45 ± 30.04 | 117.95 ± 31.77 | 113.9 ± 36.14 | < 0.001 |
Triglyceride (mg/dL) | 57.53 (57.51–57.55) | 89.88 (89.85–89.9) | 126.83 (126.78–126.87) | 218.13 (218.02–218.25) | < 0.001 |
Type 2 diabetes | 5628 (0.27) | 18,042 (0.86) | 43,375 (2.06) | 180,205 (8.55) | < 0.001 |
Hypertension | 222,942 (10.57) | 334,170 (15.84) | 450,707 (21.4) | 630,060 (29.88) | < 0.001 |
Dyslipidemia | 58,695 (2.78) | 124,995 (5.93) | 216,260 (10.27) | 395,702 (18.76) | < 0.001 |
CKD | 73,945 (3.51) | 87,512 (4.15) | 104,525 (4.96) | 131,611 (6.24) | < 0.001 |