Table 2 Cohort 1. P-values and Akaike information criterion (AIC) from binary logistic regression. Area under the curve (AUC), 95% confidence intervals (95% CI) and differences between AUCs measured with DeLong test from receiver operating characteristic (ROC) analysis. APOE stands for presence of at least one APOE ε4 allele
Cohort 1 | p | AIC | AUC | 95%CI | p value for difference with model containing N-224 alone |
|---|---|---|---|---|---|
N-224 | < 0.0001 | 54.4 | 0.851 | 0.751–0.952 | – |
Age | < 0.0001 | 53.6 | 0.853 | 0.743–0.963 | ns |
T-tau | < 0.0001 | 39.9 | 0.931 | 0.870–0.993 | 0.005 |
P-tau181 | < 0.0001 | 43.9 | 0.916 | 0.846–0.987 | ns |
N-224+T-tau | < 0.0001 | 38.8 | 0.944 | 0.889–0.999 | ns |
N-224+P-tau181 | < 0.0001 | 47.2 | 0.919 | 0.850–0.987 | ns |
N-224+APOE | < 0.0001 | 54.1 | 0.873 | 0.782–0.964 | ns |
Aβ42+P-tau181 | < 0.0001 | 17.8 | 0.991 | 0.973–1.010 | 0.004 |