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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration

Fig. 4

Role of variants in top 30 non-APOE AD risk genes in AD pathogenesis. Although most AD-associated genetic variants described to date are located in intronic or noncoding regions, these variants still could affect the nearby gene expression and exert protective or disease-inducing effects in AD-related amyloidosis, tauopathy, or neurodegeneration. Based on our analysis of all currently available data in ADNI, 11 variants were associated with brain amyloidosis, 7 variants associated with brain tauopathy, and 8 variants associated with brain neurodegeneration. Among them, variants in ADAMTS1, BZRAP1-AS1, and CELF1 affect the mechanisms involved both in brain amyloidosis and neurodegeneration, CD2AP in brain tauopathy and neurodegeneration, and SLC24A4/RIN3 in brain amyloidosis and tauopathy, implying these genes might contribute to AD risk via either common or distinct mechanisms

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Alzheimer's Research & Therapy

ISSN: 1758-9193