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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration

Fig. 3

Longitudinal effects of the variants on the change rates of brain amyloidosis, tauopathy, and neurodegeneration. a The risk C allele carrier of FERMT2 rs17125944 was associated with decreased CSF Aβ42 levels at baseline, although these changes over time were not obvious from the longitudinal analysis. b The longitudinal effect of PTK2B rs28834970 on the change rate of CSF pTau levels was significant. The minor allele carriers of PTK2B rs28834970 exhibited faster rise in CSF pTau levels. c Longitudinal effects of CELF1 rs3740688 and PICALM rs3851179 on the change rate of MRI HVa levels were significant. The minor allele carriers of CELF1 rs3740688 and PICALM rs3851179 exhibited slower decline in MRI HVa levels. d Longitudinal effects of ADAMTS1 rs2830500, CD2AP rs9381563, and CD33 rs3865444 on the change rate of FDG-PET levels were significant. The minor allele carriers of CD2AP rs9381563 exhibited faster decline in FDG-PET levels, and the minor allele carriers of ADAMTS1 rs2830500 and CD33 rs3865444 exhibited slower decline in FDG-PET levels. We analyzed the longitudinal effects of these variants on the change rates of pathology using a linear mixed effect model. The shaded regions refer to 95% confidence intervals

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