Fig. 2
Association of the variants with brain amyloidosis, tauopathy, and neurodegeneration (FDG-PET levels or MRI hippocampal volumes) at baseline. We tested for significant associations of AD risk allele carrier status with brain amyloidosis, based on CSF Aβ42 or amyloid-PET data; the associations with brain neurodegeneration, based on FDG-PET or MRI HVa data; and the associations with brain tauopathy, based on CSF pTau or tau-PET data. a The minor allele carriers of ABCA7 rs3752246, BZRAP1-AS1 rs2526378, FERMT2 rs17125944, SLC24A4/RIN3 rs10498633, and SLC24A4/RIN3 rs12590654 were significantly associated with decreased CSF Aβ42 levels, and ADAM10 rs593742, IGHV1-68 rs79452530, and CELF1 rs3740688 associated with increased CSF Aβ42 levels. b The minor allele carriers of ABCA7 rs3752246 were associated with increased amyloid-PET levels, and ADAMTS1 rs2830500, CLU rs11136000, and EPHA1 rs11771145 associated with decreased levels of amyloid-PET. c The minor allele carriers of BZRAP1-AS1 rs2526378 and HS3ST1 rs6448807 were associated with decreased FDG-PET levels. d The minor allele carriers of ECHDC3 rs11257242 were associated with increased MRI HVa levels. e The minor allele carriers of BIN1 rs744373 and BIN1 rs6733839 had lower CSF pTau levels, and CD2AP rs9381563 and INPP5D rs10933431 had higher CSF pTau levels. f The minor allele carriers of BIN1 rs744373 and BIN1 rs7561528 had higher tau-PET levels, and SLC24A4/RIN3 rs10498633 had lower tau-PET levels