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Table 1 Characteristics of the sample with genetic and plasma p-tau 181 data

From: Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative

 

CU (n = 236)

MCI (n = 434)

AD (n = 148)

 
    

pa

Age in years, mean (SD)

73.8 (6.1)

72.6 (7.8)

75.5 (7.9)

1e−4

Sex (women), n (%)

132 (55.9)

181 (41.7)

56 (37.8)

3e−4

APOE ε4, n (%)

69 (29.2)

176 (40.6)

101 (68.2)

2e−12

plasma p-tau 181, mean (SD)

14.9 (8.7)

18.3 (11.0)

23.6 (8.2)

2e−15

Years of education, mean (SD)

16.6 (2.7)

16.1 (2.8)

16.0 (2.7)

0.05

Aβ positivityb, n (%)

45 (21.0)

176 (45.6)

101 (77.1)

2e−23

APOE PRSs, median (min, max)

   

pc

pd

 34-SNP PRS

− 0.63 (− 2.22, 2.04)

− 0.15 (− 1.74, 2.85)

0.45 (− 1.94, 2.89)

–

  OR (95% CI)

ref

1.66 (1.37–2.02)

2.97 (2.24–3.95)

3e−7

5e−14

 5e−8 PRS

− 0.62 (− 2.48, 1.91)

− 0.20 (− 1.90, 2.52)

0.41 (− 1.83, 2.64)

–

  OR (95% CI)

ref

1.69 (1.39–2.05)

2.88 (2.18–3.80)

2e−7

1e−13

 1e−5 PRS

− 0.56 (− 2.35, 2.08)

− 0.17 (− 2.26, 2.98)

0.40 (− 2.08, 3.14)

–

  OR (95% CI)

ref

1.73 (1.42–2.11)

3.20 (2.37–4.31)

4e−8

2e−14

 PHS

− 0.66 (− 2.39, 2.03)

− 0.23 (− 1.89, 2.45)

0.48 (− 1.96, 2.78)

–

  OR (95% CI)

ref

1.76 (1.44–2.15)

3.31 (2.46–4.45)

3e−8

2e−15

non-APOE PRSs, median (min, max)

   

pc

pd

 34-SNP PRS

− 0.14 (− 2.49, 2.88)

− 0.02 (− 2.32, 2.75)

− 0.03 (− 2.69, 3.62)

–

  OR (95% CI)

ref

1.11 (0.94–1.30)

1.26 (1.02–1.56)

0.2

0.04

 5e−8 PRS

− 0.12 (− 2.36, 2.92)

− 0.02 (− 3.33, 3.06)

− 0.01 (− 2.47, 3.12)

–

  OR (95% CI)

ref

1.13 (0.96–1.33)

1.21 (0.97–1.51)

0.2

0.1

 1e−5 PRS

− 0.21 (− 2.58, 2.61)

− 0.02 (− 3.43, 2.90)

0.08 (− 2.53, 2.82)

–

  OR (95% CI)

ref

1.21 (1.02–1.42)

1.34 (1.07–1.68)

0.03

0.01

Aβ pos (n = 322)

   

pa

 Age in years, mean (SD)

72.2 (5.3)

73.9 (6.8)

74.0 (7.9)

0.5

 Sex (women), n (%)

32 (71.1)

70 (39.8)

45 (44.6)

1e−3

 APOE ε4, n (%)

25 (55.6)

117 (66.5)

81 (80.2)

6e−3

 Plasma p-tau 181, mean (SD)

18.5 (7.8)

23.0 (10.8)

25.0 (8.4)

1e−3

 Years of education, mean (SD)

16.2 (2.5)

15.9 (2.8)

15.9 (2.7)

0.8

Aβ neg (n = 409)

   

pa

 Age in years, mean (SD)

73.3 (6.3)

71.1 (8.0)

78.1 (6.2)

9e−7

 Sex (women), n (%)

85 (50.3)

91 (43.3)

6 (20.0)

8e−3

 APOE ε4, n (%)

37 (21.9)

74 (35.2)

9 (30.0)

0.02

 Plasma p-tau 181, mean (SD)

14.3 (8.9)

14.5 (9.6)

19.2 (7.1)

0.02

 Years of education, mean (SD)

16.7 (2.7)

16.4 (2.7)

16.2 (2.6)

0.4

  1. Significant p values are shown in bold
  2. aBased on ANOVA for continuous variables and chi-square test for categorical variables
  3. bAβ pathology status was missing for 87 individuals
  4. cBased on logistic regression including cognitively unimpaired (ref) and MCI
  5. dBased on logistic regression including cognitively unimpaired (ref) and AD
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Alzheimer's Research & Therapy

ISSN: 1758-9193