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Table 3 Details for logistic regression analyses and criterion values from the ROC curves

From: Performance of the QPLEX™ Alz plus assay, a novel multiplex kit for screening cerebral amyloid deposition

 

Logistic regression

Criterion values

Model

n

Significance

R2

Chi2

Cutoff

Sensitivity, % (95% CI)

Specificity, % (95% CI)

ApoE

300

< 0.0001

0.32

81.9

> 0.4067

76.67 (69.1–83.2)

68.00 (59.9–75.4)

QPLEX™

292

< 0.0001

0.45

120.8

> 0.4566

76.55 (68.8–83.2)

73.47 (65.6–80.4)

ApoE + QPLEX™

292

< 0.0001

0.59

172.5

> 0.4224

80.00 (72.6–86.2)

82.99 (75.9–88.7)

  1. Eight samples were excluded as outliers by Grubb’s test (p < 0.05, double sides)
  2. Age and sex were used as covariates
  3. R2 Nagelkerke R2, Chi2 chi-squared test, CI confidence interval, ROC receiver operating characteristics