Characteristics (n) | CN− (113) | CN+ (36) | MCI− (31) | MCI+ (56) | DEM− (6) | DEM+ (58) | P value |
---|---|---|---|---|---|---|---|
Gender, M/F | 46/67 | 20/16 | 10/21 | 17/39 | 2/4 | 18/40 | > 0.1† |
Age, years, mean ± SEM | 67.32 ± 0.8 | 74.47 ± 1.0 | 73.58 ± 0.1 | 73.23 ± 0.9 | 75.66 ± 4.3 | 72.28 ± 1.0 | < 0.001* |
Education, mean ± SEM | 11.39 ± 0.5 | 12.08 ± 0.8 | 9.2 ± 0.8 | 10.16 ± 0.6 | 6.00 ± 1.7 | 9.67 ± 0.7 | < 0.01* |
MMSE, mean ± SEM | 26.96 ± 0.2 | 27.16 ± 0.4 | 22.93 ± 0.6 | 21.73 ± 0.4 | 18.17 ± 3.0 | 16.59 ± 0.5 | < 0.001* |
MMSE z, mean ± SEM | 0.29 ± 0.1 | 0.44 ± 0.1 | − 0.91 ± 0.2 | − 1.54 ± 0.2 | − 2.08 ± 0.2 | − 3.23 ± 0.2 | < 0.001* |
CDR (n) | 0 (113) | 0 (36) | 0.5 (31) | 0.5 (56) | 0.5 (2), 1 (4) | 0.5 (17), 1 (41) | < 0.001† |
ApoE4 status, ε4+/N | 20/113 | 12/36 | 2/31 | 33/56 | 0/6 | 40/58 | < 0.001† |
PiB (SUVR), mean ± SEM | 1.10 ± 0.01 | 1.62 ± 0.05 | 1.13 ± 0.01 | 1.92 ± 0.04 | 1.10 ± 0.02 | 2.10 ± 0.05 | < 0.001* |