Change in cognitive function according to cholinesterase inhibitor use and amyloid PET positivity in patients with mild cognitive impairment

Table 3 Change in cognitive function after 1 year according to group and association with amyloid burden as analyzed by linear regression analysis

Change in	β (SE), p value	β (SE), p value Including amyloid PET result
MMSE	0.486 (0.720), 0.503	0.488 (0.718), 0.499
CDR SOB	− 0.460 (0.367), 0.217	− 0.460 (0.371), 0.221
Geriatric Depression Scale	− 0.810 (1.074), 0.455	− 0.821 (1.084), 0.453
Digit Span Forward Test	− 0.024 (0.198), 0.901	− 0.015 (0.199), 0.938
Digit Span Backward Test	0.004 (0.233), 0.985	0.030 (0.227), 0.894
Korean Boston Naming Test	0.088 (0.221), 0.692	0.088 (0.223), 0.694
SVLT Immediate recall	0.024 (0.171), 0.887	0.024 (0.173), 0.888
SVLT Delayed recall	− 0.162 (0.127), 0.208	− 0.162 (0.127), 0.210
SVLT Recognition	0.136 (0.206), 0.511	0.136 (0.207), 0.514
RCFT Copy	0.110 (0.235), 0.642	0.110 (0.236), 0.644
RCFT Delayed recall	− 0.119 (0.127), 0.355	− 0.116 (0.128), 0.371
RCFT Recognition	0.385 (0.284), 0.183	0.378 (0.288), 0.198
Categorical fluency	0.215 (0.161), 0.189	0.215 (0.161), 0.189
Phonemic fluency	− 0.132 (0.209), 0.530	− 0.132 (0.196), 0.503
Stroop Colors Test	0.153 (0.174), 0.384	0.153 (0.174), 0.382

The dependent variable was the change in cognitive test scores over 1 year. The independent variable was the group (ChEI user vs ChEI non-user). The amyloid PET result was adjusted. Age, sex, and educational level were also adjusted in the MMSE analysis. β values (standard error, SE) of the dependent variable are presented by group. Raw scores were used for the CDR SOB and Geriatric Depression Scale, and z-scores were used for the rest of the neuropsychological tests

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