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Table 1 Demographic data and core AD biomarker levels for the clinical studya

From: Full-length and C-terminal neurogranin in Alzheimer’s disease cerebrospinal fluid analyzed by novel ultrasensitive immunoassays

 

Control

MCI-AD

AD

Number (Women/Men)

26 (17/9)

18 (13/5)

23 (17/6)

Age (years)

62 (53–69), P = 0.007c

70 (69–78), P = 0.007b

68 (64–72)

MMSE

27 (25–28)

27 (26–28)

22 (16–24), P < 0.00001b, P = 0.00002c

1–42 (ng/L)

970 (811–1091), P = 0.00002c

558 (377–667), P < 0.00002b

496 (459–568), P < 0.00001b

T-tau (ng/L)

182 (154–207), P < 0.00001c

570 (520–717), P < 0.00001b

618 (527–734), P < 0.00001b

P-tau (ng/L)

35 (30–41), P < 0.00001c

86 (79–104), P < 0.00001b

90 (73–108), P < 0.00001b

  1. aData are given as median (interquartile range) unless otherwise indicated. Statistical differences were determined using non-parametric tests. The demographic data and the core AD biomarkers have partially previously been reported [6]
  2. bCompared with controls
  3. cCompared with MCI-AD