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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer’s disease

Fig. 3

Long-term knockout reduces volume and plaque number, accompanied by cerebral amyloid angiopathy (CAA) onset. a Hemisphere stitches microglia (Iba1 green) amyloid plaque (6E10 red) in 6- and 8-month-old APPSwe/PS1 and APP cKO, scale bar = 500 μm. be Unbiased stereological analysis of plaques in the hippocampus and cortex. Analysis has shown a reduction in plaque volume at 6 (hippocampus *p = 0.0354, cortex *p = 0.0479) and at 8 months (hippocampus *p = 0.0320, cortex *p = 0.0227) in APP cKO. A reduction in the number of plaque/mm3 in the cortex (*p = 0.0270). APPSwe/PS1 6m, n = 6, n = 6 for APP cKO 6m. f Elisa Aβ40 APP cKO 6 and 8 months old and their controls. APPSwe/PS1 (6–8m) n = 6 and APP cKO (6–8m) n = 7 (**p = 0.0098). g Frequency of CAA in APPSwe/PS1 and APP cKO at 8 months old, n = 4 (***p = 0.0002). h Western blot analysis for ABCB1 between APP cKO (6–8m) and their control. APPSwe/PS1 (6–8m) n = 6, n = 7 APP cKO (6–8m) (*p = 0.023). i Representative images of amyloid (6E10 red) on blood vessels (CD31 green) in APPSwe/PS1 and APP cKO at 6 and 8 months old. Scale bar = 50 μm

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