Fig. 1

CSF1R deletion is solely deleted in microglia. a Experimental design. b Genetic construction of Cre/Lox system. c Timeline starting at 3 months. d Representative image of microglia (Iba1 green, Cre-recombination reporter gene Red^tm) in WT and cKO. Scale bar = 200 μm. e Quantification of the average percentage of Red^tm+/Iba1⁺ cells in Rosa^redTm-CSF1R-lox/CX3CR1-Cre/ER without tamoxifen (ctl cKO^redtm) or with tamoxifen (cKO^redtm) n = 4 in each group. e Representative image of CSF1R staining in immunohistochemistry using 3-month-old WT and cKO mice. Scale bar = 200 μm. f Analysis of CSF1R staining at 3-month-old WT and cKO mice n = 4 in each group. (****p < 0.0001)