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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Trichostatin A ameliorates Alzheimer’s disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice

Fig. 3

TSA shifted albumin-Aβ complexes to the blood vessels of cerebral falx in APP/PS1 mice and promoted the endocytosis of Aβ oligomers by bEnd.3 cells. a, b Representative images showing Aβ co-localized with albumin in the hippocampus of APP/PS1 mice. Thioflavin S (ThioS), green; albumin, red; DAPI, blue. Scale bar in a: 200 μm. Scale bar in b: 10 μm. Yellow arrows indicate representative positive staining. c Western blots and d, e quantitative analysis for albumin and Aβ (6E10) in bEnd.3 cells. n = 3–5 per group. *p < 0.05 and ***p < 0.001

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