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Table 3 Correlation of regional Aβ deposition and regional SV2A in aMCI and dementia due to AD

From: Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

 

Mild cognitive impairment (n = 14)

Dementia (n = 24)

Primary region

Pearson r

P

Pearson r

P

Hippocampus

0.40

0.16

0.63

0.001*

Exploratory regions

Pearson r

P

Pearson r

P

Entorhinal

− 0.01

0.96

0.29

0.17

Parahippocampal

− 0.45

0.10

0.18

0.40

Amygdala

0.03

0.92

0.35

0.09

Lateral temporal

− 0.24

0.40

− 0.10

0.64

Prefrontal

− 0.04

0.88

− 0.28

0.19

PCC/precuneus

− 0.06

0.83

− 0.23

0.29

Anterior cingulate

0.14

0.63

0.02

0.93

Lateral parietal

− 0.13

0.65

− 0.26

0.22

Lateral occipital

− 0.02

0.96

− 0.32

0.12

Medial occipital

0.03

0.91

− 0.46

0.02*

Pericentral

0.09

0.77

− 0.12

0.58

  1. Data are Pearson r and associated two-tailed P values obtained from separate univariate linear regression analyses in each group, uncorrected for multiple comparisons. Correlations between regional [11C] PiB and [11C]UCB-J DVR were assessed within 4 medial temporal structures and 8 neocortical ROIs. * denotes P < 0.05. Abbreviations: PCC posterior cingulate cortex, PiB Pittsburgh Compound B, SV2A synaptic vesicle glycoprotein 2A, DVR distribution volume ratio using a whole cerebellum reference region, ROI region of interest, aMCI amnestic mild cognitive impairment
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Alzheimer's Research & Therapy

ISSN: 1758-9193