Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

Table 2 Correlation of global Aβ deposition and regional SV2A in aMCI and dementia due to AD

Data are Pearson r and associated two-tailed P values obtained from separate univariate linear regression analyses in each group, uncorrected for multiple comparisons. Global Aβ deposition was calculated by averaging values of [¹¹C] PiB DVR from the bilateral prefrontal, lateral temporal, posterior cingulate/precuneus, and lateral parietal ROIs, weighted by volume. Global Aβ deposition was then correlated with [¹¹C]UCB-J DVR from the 4 medial temporal structures and 8 neocortical ROIs. To determine significant differences between group correlation coefficients, Fisher z-transformations and associated one-tailed P values were reported. * denotes significant correlation, with P < 0.05. Abbreviations: PCC posterior cingulate cortex, PiB Pittsburgh Compound B, SV2A synaptic vesicle glycoprotein 2A, DVR distribution volume ratio using a whole cerebellum reference region, ROI region of interest, aMCI amnestic mild cognitive impairment

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