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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

Fig. 3

Brain maps of correlations between global Aβ deposition and SV2A in aMCI and dementia. Brain maps were created by producing images with the voxels in each FreeSurfer region set uniformly to the calculated Pearson r for that region and overlaid on an MNI template T1 MRI. Correlations were across all 84 lateralized FreeSurfer brain regions and displayed only for regions with uncorrected P < 0.05 in both the a aMCI and b dementia diagnostic groups. MR image slices adhere to radiological convention, with orientation denoted in the first coronal section of each image series. Abbreviations: DVR, distribution volume ratio using a whole cerebellum reference region; aMCI, amnestic mild cognitive impairment

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