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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease

Fig. 2

Inter-group metabolite differences. Boxplots highlighting differences between metabolite concentrations in serum and urine when comparing AD (red), MCI (blue = sMCI, yellow = cMCI) and age-matched controls (CTL—green). Boxplots are shown for metabolites in the serotonin and kynurenine pathways that reported significant differences following univariate Kruskal-Wallis tests. Figure p values were calculated using Dunn’s post hoc test for those metabolites that reported a Kruskal-Wallis p value < 0.1 following adjustment for multiple testing using the Holm method. A decreasing trend was observed: control > MCI > AD for each metabolite. This trend was observed regardless of gender (Fig. 3). Boxplots for all metabolites are presented in Fig. S1 and S2

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Alzheimer's Research & Therapy

ISSN: 1758-9193