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Table 2 Cox proportional hazard models for Aβ misfolding when unadjusted and adjusted for the risk factors sex, age, and APOEε4. HR hazard ratio

From: Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

  Unadjusted model
(Aβ misfolding)
Adjusted model
(Aβ misfolding)
HR (95% CI) p value HR (95% CI) p value
APOE carrier Not included   3.3 (1.3, 8.1) 0.01
Age Not included   1.09 (1.02, 1.15) 0.008
Sex Not included   1.8 (0.8, 4.5) 0.2
Aβ misfolding
 Low misfolding vs normal folding 4.6 (0.6, 38.5) 0.159 10.7 (1.05, 110.1) 0.046
 High misfolding vs normal folding 14.0 (1.8, 105.7) 0.011 18.8 (2.2, 157.8) 0.007
Observations 203   203  
R2 0.073   0.159  
  Adjusted model
(Aβ42/40 ratio)
Full model
(Aβ misfolding + Aβ42/40 ratio)
HR (95% CI) p value HR (95% CI) p value
APOE carrier 2.7 (1.1, 6.7) 0.034 3.0 (1.2, 7.4) 0.021
Age 1.05 (0.997, 1.113) 0.07 1.07 (1.0, 1.14) 0.049
Sex 1.6 (0.7, 3.8) 0.3 1.3 (0.5, 3.4) 0.6
Aβ misfolding Not included    
 Low misfolding vs normal folding    9.3 (0.9,91.1) 0.057
 High misfolding vs normal folding    17.0 (2.1, 139.8) 0.009
42/40 ratio 0.9 (0.8, 0.99) 0.024 0.9 (0.87, 0.998) 0.046
Observations 203   203  
R2 0.120   0.178