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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

Fig. 4

a Time-dependent ROC (t-ROC) curves for all three biomarker models. In addition to the structure biomarker, the risk factors age, sex, and APOEε4 status were also included (red). In addition, t-ROC analyses for the Aβ42/40 biomarker in plasma are shown in blue. Considering the risk factors and both plasma biomarkers in a panel, the AUC increased considerably with the risk biomarker panel (green). b T-ROC curve analysis overview for the 6-year follow-up period in each model. The time course of the structure biomarker, including the risk factors age, sex, and APOEε4, is shown in red. In blue, the Aβ42/40 ratio biomarker is shown, and the biomarker panel including risk factors and both plasma markers is shown in green. The biomarker panel shows an increase in performance compared to the plasma markers alone. c AUC values with confidence intervals for all models within 6 years. Model 1 represents the performance of the structure biomarker (adjusted model), and Model 2 shows the performance of the Aβ42/40 ratio and the risk panel including both plasma biomarkers in an adjusted model

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