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Table 1 Model characteristics, population characteristics, costs and utilities

From: Economic evaluation of supplementing the diet with Souvenaid in patients with prodromal Alzheimer’s disease

 

Source

Model characteristics

 Number of patients

100,000

 

 Number of replications

1

 

 Discount rate

3%

 

 Cut-off for mild AD

4.5

[15]

 Cut-off for moderate AD

9.5

[15]

Population characteristics

 % male

0.46

[9]

 Age

Mean (SD)

70.7 (6.2)

[9]

 AgeCaregiver

Mean (SD)

55.2 (14.5)

[18]

 Site (%)

1, 2, 3, 4, 5

10, 10, 50, 10, 20

[14]

 Baseline MMSE score

Mean (SD)

27.0 (5.3)

[9]

Annual costs (mean)

 

[18]

 Souvenaid

€1200

 

 Diagnosis

€2900

[19]

 Mild AD (health care)

€3388

 

 Mild AD (social care)

€13,927

 

 Mild AD (indirect)

€647

 

 Mild AD (total)

€17,962

 

 Moderate/severe AD (health care)

€4659

 

 Moderate/severe AD (social care)

€34,893

 

 Moderate/severe AD (indirect)

€820

 

 Moderate/severe AD (total)

€40,372

 

Utilities

 MCI

Age 40–49

0.84

[20]

 

Age 50–59

0.91

[20]

 

Age 60–69

0.90

[20]

 

Age 70–79

0.84

[20]

 

Age 80–89

0.72

[20]

 

Age ≥ 90

0.58

[20]

 Mild AD

Mean

0.52

[18]

 Moderate AD

Mean

0.21

[18]

 MCI caregiver

Mean

Depending on age

[20]

 Mild AD caregiver

Mean

0.71

[18]

 Moderate AD caregiver

Mean

0.65

[18]

  1. AD Alzheimer’s disease, OC other causes, MCI mild cognitive impairment, CDR-SB Clinical Dementia Rating-Sum of Boxes, MMSE Mini-Mental State Exam