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Table 1 The demographic characteristics, clinical comorbidities, and biomarker results of the study population

From: Identification and validation of endogenous control miRNAs in plasma samples for normalization of qPCR data for Alzheimer’s disease

  Screening study Stability assessment study
AD, N = 19, mean (SD), median [IQR] or n (%) CTL, N = 24, median [IQR] or n (%) MCI −, N = 25, median [IQR] or n (%) MCI +, N = 22, median [IQR] or n (%) AD, N = 55, median [IQR] or n (%) P value
Sociodemographic characteristics
 Sex, female 19 (100%) 16 (66.7%) 15 (60.0%) 11 (50.0%) 23 (41.8%) 0.096
 Age, years 75.2 (5.68) 68.0 [62.5; 73.0] 69.0 [63.0; 74.0] 73.0 [70.0; 77.0] 73.0 [68.7; 79.0] 0.001
Alzheimer parameters
 MMSE   30.0 [28.8; 30.0] 25.0 [23.0; 27.0] 27.0 [25.0; 28.0] 24.0 [22.0; 25.5] < 0.001
 Aβ42 484 [382; 532] 1086 [972; 1419] 846 [689; 960] 491 [422; 541] 430 [340; 530] < 0.001
 T-tau 601 [494; 734] 298 [222; 416] 237 [193; 265] 638 [530; 728] 563 [335; 846] < 0.001
 P-tau 91.0 [76.8; 114] 52.8 [43.8; 62.3] 43.7 [38.5; 48.4] 85.8 [77.5; 111] 80.4 [55.0; 104] < 0.001
Comorbidities
 Depression 7 (36.8%) 7 (29.2%) 11 (44.0%) 7 (31.8%) 16 (29.1%) 0.588
 Hypertension 13 (68.4%) 8 (33.3%) 14 (56.0%) 8 (36.4%) 30 (54.5%) 0.184
 Diabetes mellitus 3 (15.8%) 5 (20.8%) 6 (24.0%) 2 (9.09%) 10 (18.2%) 0.593
 Dyslipidemia 8 (42.1%) 10 (41.7%) 9 (36.0%) 10 (45.5%) 19 (34.5%) 0.807