Table 1 The demographic characteristics, clinical comorbidities, and biomarker results of the study population
Screening study | Stability assessment study | |||||
|---|---|---|---|---|---|---|
AD, N = 19, mean (SD), median [IQR] or n (%) | CTL, N = 24, median [IQR] or n (%) | MCI −, N = 25, median [IQR] or n (%) | MCI +, N = 22, median [IQR] or n (%) | AD, N = 55, median [IQR] or n (%) | P value | |
Sociodemographic characteristics | ||||||
Sex, female | 19 (100%) | 16 (66.7%) | 15 (60.0%) | 11 (50.0%) | 23 (41.8%) | 0.096 |
Age, years | 75.2 (5.68) | 68.0 [62.5; 73.0] | 69.0 [63.0; 74.0] | 73.0 [70.0; 77.0] | 73.0 [68.7; 79.0] | 0.001 |
Alzheimer parameters | ||||||
MMSE | 30.0 [28.8; 30.0] | 25.0 [23.0; 27.0] | 27.0 [25.0; 28.0] | 24.0 [22.0; 25.5] | < 0.001 | |
Aβ42 | 484 [382; 532] | 1086 [972; 1419] | 846 [689; 960] | 491 [422; 541] | 430 [340; 530] | < 0.001 |
T-tau | 601 [494; 734] | 298 [222; 416] | 237 [193; 265] | 638 [530; 728] | 563 [335; 846] | < 0.001 |
P-tau | 91.0 [76.8; 114] | 52.8 [43.8; 62.3] | 43.7 [38.5; 48.4] | 85.8 [77.5; 111] | 80.4 [55.0; 104] | < 0.001 |
Comorbidities | ||||||
Depression | 7 (36.8%) | 7 (29.2%) | 11 (44.0%) | 7 (31.8%) | 16 (29.1%) | 0.588 |
Hypertension | 13 (68.4%) | 8 (33.3%) | 14 (56.0%) | 8 (36.4%) | 30 (54.5%) | 0.184 |
Diabetes mellitus | 3 (15.8%) | 5 (20.8%) | 6 (24.0%) | 2 (9.09%) | 10 (18.2%) | 0.593 |
Dyslipidemia | 8 (42.1%) | 10 (41.7%) | 9 (36.0%) | 10 (45.5%) | 19 (34.5%) | 0.807 |