Fig. 2
From: Exploring the role of RALYL in Alzheimer’s disease reserve by network-based approaches
Module to phenotype network (MPN). a WGCNA hierarchical clustering dendrograms of identified eleven distinct modules of highly co-expressed genes; all modules are marked with different colors. b The correlation between modules and phenotypes. Heatmaps of the correlation between eigengene and AD phenotypes (covariates: age, sex, PMI), each cell contains the corresponding correlation and p value, and the correlations between module 11 and AD phenotypes: diagnostic group (cor = − 0.63, adjusted p = 0.4 × 10−3), reserve (cor = 0.39, adjusted p = 0.04), MMSE (cor = 0.68, adjusted p = 0.1 × 10−3), and Braak (cor = − 0.42, adjusted p = 0.02). c A directed acyclic graph, obtained using Bayesian network structure learning, represents the relationships between modules (circles), three relevant AD phenotypes (NFTs, Braak scores, and cognitive performance (MMSE); diamonds), and AD reserve (squares). The diameter of the circles is proportional to the number of genes in the module. The color of the module corresponds to the legend and represents the results of Gene Ontology (GO) analysis of each module