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Table 5 Adjusted odds ratio in 5-year cognitive change per 10 mg/dL lipids at baseline across all sensitivity analyses, OR (95%CI)

From: Sex-specific associations between lipids and cognitive decline in the middle-aged and elderly: a cohort study of Chinese adults

  Global cognition Mental status Episodic memory
Male Female   Male Female   Male Female  
Sensitivity: Restrict to those fasting > 8 h
 Total cholesterol 1.00 (0.98, 1.02) 1.02 (1.00, 1.05) 1.00 (0.98,1.02) 1.03 (1.00, 1.05) * 1.00 (0.98, 1.02) 1.00 (0.98, 1.02)
 LDL-c 1.00 (0.98, 1.02) 1.03 (1.00, 1.05) * 1.00 (0.98, 1.02) 1.04 (1.01, 1.06) ** 1.00 (0.98, 1.03) 1.00 (0.97, 1.02)
 HDL-c 0.95 (0.90, 1.00) 1.07 (1.00, 1.14) 0.94 (0.89,0.99) * 1.04 (0.98, 1.11) 0.97 (0.92, 1.02) 1.06 (0.99, 1.13)
 Triglycerides 1.01 (0.99, 1.02) 0.99 (0.98, 1.00) 1.00 (0.99, 1.02) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01)
Sensitivity: Impute those with a global cognition score of less than or equal to 5
 Total cholesterol 1.00 (0.98, 1.02) 1.02 (1.00, 1.04) * 1.00 (0.98, 1.02) 1.03 (1.01, 1.05) * 1.00 (0.98, 1.02) 1.00 (0.98, 1.03)
 LDL-c 1.00 (0.97, 1.02) 1.02 (1.00, 1.04) 0.99 (0.97, 1.02) 1.03 (1.01, 1.06) ** 1.00 (0.98, 1.03) 1.00 (0.97, 1.02)
 HDL-c 0.96 (0.91, 1.01) 1.04 (0.98, 1.10) 0.95 (0.90, 1.00) * 1.04 (0.98, 1.11) 0.97 (0.92, 1.02) 1.06 (1.00, 1.13)
 Triglycerides 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01)
Sensitivity: Impute those with severe diseases or conditions known to affect cognitive function
 Total cholesterol 1.00 (0.98, 1.02) 1.02 (1.00, 1.03) 1.00 (0.98, 1.02) 1.03 (1.01, 1.05) * 1.00 (0.98, 1.02) 1.00 (0.98, 1.03)
 LDL-c 1.00 (0.98, 1.02) 1.01 (0.99, 1.03) 0.99 (0.97, 1.02) 1.03 (1.01, 1.06) ** 1.00 (0.98, 1.03) 1.00 (0.97, 1.02)
 HDL-c 0.96 (0.91, 1.00) 1.02 (0.97, 1.07) 0.95 (0.90, 1.00) * 1.04, 0.98, 1.11) 0.97 (0.92, 1.02) 1.06 (1.00, 1.13)
 Triglycerides 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01) 1.00 (0.99, 1.01)
  1. OR odds ratio, CI confidence interval, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol
  2. *P < 0.05
  3. **P < 0.01
  4. Adjusted for baseline age, education, marital status, registered residence, body mass index, alcohol use, smoking status, diabetes, hypertension, social activity, health insurance status, and lipid-lowering medication use